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Substance Name: Lidocaine hydrochloride
RN: 73-78-9
UNII: EC2CNF7XFP
InChIKey: IYBQHJMYDGVZRY-UHFFFAOYSA-N
Note
- A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Molecular Formula
- C14-H22-N2-O.Cl-H
Molecular Weight
- 270.8017
- All
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
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Names and Synonyms
Results Name
- Lidocaine hydrochloride
Name of Substance
- Lidocaine hydrochloride anhydrous
Synonyms
- 2-Diethylamino-2',6'-acetoxylidide hydrochloride
- alpha-Diethylamino-2,6-acetoxylidine hydrochloride
- Alphacaine
- Alphacaine hydrochloride
- Anestacon
- Anestacon hydrochloride
- Duncaine hydrochloride
- EINECS 200-803-8
- Glydo
- Gravocain hydrochloride
- Isicaine hydrochloride
- Laryng-O-jet
- Laryng-O-Jet kit
- Laryngotracheal anesthesia kit
- Leostesin hydrochloride
- Lidocain hydrochloride
- Lidocaine HCl
- Lidocaine hydrochloride
- Lidocaine hydrochloride 0.1% and dextrose 5% in plastic container
- Lidocaine hydrochloride 0.2% and dextrose 5% in plastic container
- Lidocaine hydrochloride 0.2% in dextrose 5%
- Lidocaine hydrochloride 0.2% in dextrose 5% in plastic container
- Lidocaine hydrochloride 0.4% and dextrose 5% in plastic container
- Lidocaine hydrochloride 0.4% in dextrose 5%
- Lidocaine hydrochloride 0.4% in dextrose 5% in plastic container
- Lidocaine hydrochloride 0.8% and dextrose 5% in plastic container
- Lidocaine hydrochloride 0.8% in dextrose 5% in plastic container
- Lidocaine hydrochloride 5% and dextrose 7.5%
- Lidocaine hydrochloride in plastic container
- Lidocaine hydrochloride preservative free
- Lidocaine hydrochloride preservative free in plastic container
- Lidocaine hydrochloride viscous
- Lidocaine Viscous
- Lidocaton
- Lidopen
- Lidothesin
- Lidothesin hydrochloride
- Lignocaine hydrochloride
- Lta II kit
- N-(Diethylaminoacetyl)-2,6-dimethylaniline hydrochloride
- NSC 757420
- omega-Diethylamino-2,6-dimethylacetanilide hydrochloride
- Pediatric LTA kit
- Rucaina hydrochloride
- S 202
- UNII-EC2CNF7XFP
- V 262
- Xilina hydrochloride
- Xycaine hydrochloride
- Xylestesin hydrochloride
- Xylocaine
- Xylocaine 1.5% w/ dextrose 7.5%
- Xylocaine 4% preservative free
- Xylocaine 5% w/ glucose 7.5%
- Xylocaine hydrochloride
- Xylocaine preservative free
- Xylocaine viscous
- Xylocard
- Xylocitin hydrochloride
- Xyloneural
- Xylotox
- Xylotox hydrochloride
- Zingo
Systematic Names
- 2',6'-Acetoxylidide, 2-(diethylamino)-, hydrochloride
- 2',6'-Acetoxylidide, 2-(diethylamino)-, monohydrochloride (8CI)
- Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)
- Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride
- Lidocaine hydrochloride
Registry Numbers
CAS Registry Number
- 73-78-9
FDA UNII
- EC2CNF7XFP
Related Registry Number
- 137-58-6 (Parent)
System Generated Number
- 0000073789
Molecular Formulas
Molecular Formula
- C14-H22-N2-O.Cl-H
Molecular Formula Fragments
- C14-H22-N2-O
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1HInChIKey
IYBQHJMYDGVZRY-UHFFFAOYSA-NSmiles
Cl.CCN(CC)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | intravenous | 60mg/kg/1H (60mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Toxicology, Clinical Toxicology. Vol. 24, Pg. 51, 1986. |
dog | LDLo | intravenous | 65700ug/kg (65.7mg/kg) | Journal de Pharmacologie. Vol. 2, Pg. 240, 1971. | |
frog | LD50 | parenteral | 159mg/kg (159mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 289, Pg. 278, 1987. | |
guinea pig | LD50 | intravenous | 24500ug/kg (24.5mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. | |
infant | TDLo | intravenous | 10mg/kg (10mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Toxicology, Clinical Toxicology. Vol. 28, Pg. 101, 1990. |
infant | TDLo | oral | 1600ug/kg/9H- (1.6mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Annals of Emergency Medicine. Vol. 17, Pg. 725, 1988. |
infant | TDLo | oral | 1632mg/kg/1W- (1632mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Clinical Pediatrics Vol. 22, Pg. 190, 1983. |
man | TDLo | implant | 5714ug/kg (5.714mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Canadian Medical Association Journal. Vol. 137, Pg. 219, 1987. |
man | TDLo | intravenous | 7143ug/kg (7.143mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Chest. Vol. 61, Pg. 682, 1972. |
man | TDLo | intravenous | 9mg/kg/4H-C (9mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION | Drug Intelligence and Clinical Pharmacy. Vol. 19, Pg. 669, 1985. |
mouse | LD50 | intramuscular | 177mg/kg (177mg/kg) | Drug Development Research. Vol. 21, Pg. 277, 1990. | |
mouse | LD50 | intraperitoneal | 63mg/kg (63mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 274, Pg. 253, 1985. | |
mouse | LD50 | intravenous | 15mg/kg (15mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of Pharmacy and Pharmacology. Vol. 14, Pg. 48T, 1962. |
mouse | LD50 | oral | 220mg/kg (220mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970. | |
mouse | LD50 | subcutaneous | 163mg/kg (163mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 103, Pg. 353, 1960. | |
rabbit | LD50 | intratracheal | 28mg/kg (28mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972. | |
rabbit | LD50 | intravenous | 25600ug/kg (25.6mg/kg) | Drugs in Japan Vol. 6, Pg. 879, 1982. | |
rat | LD50 | intraperitoneal | 122mg/kg (122mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 111, Pg. 224, 1954. | |
rat | LD50 | intravenous | 21mg/kg (21mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970. | |
rat | LD50 | subcutaneous | 570mg/kg (570mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970. |