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Substance Name: Lidocaine hydrochloride
RN: 73-78-9
UNII: EC2CNF7XFP
InChIKey: IYBQHJMYDGVZRY-UHFFFAOYSA-N

Note

  • A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

Molecular Formula

  • C14-H22-N2-O.Cl-H

Molecular Weight

  • 270.8017
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
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Names and Synonyms

Results Name

  • Lidocaine hydrochloride

Name of Substance

  • Lidocaine hydrochloride anhydrous

Synonyms

  • 2-Diethylamino-2',6'-acetoxylidide hydrochloride
  • alpha-Diethylamino-2,6-acetoxylidine hydrochloride
  • Alphacaine
  • Alphacaine hydrochloride
  • Anestacon
  • Anestacon hydrochloride
  • Duncaine hydrochloride
  • EINECS 200-803-8
  • Glydo
  • Gravocain hydrochloride
  • Isicaine hydrochloride
  • Laryng-O-jet
  • Laryng-O-Jet kit
  • Laryngotracheal anesthesia kit
  • Leostesin hydrochloride
  • Lidocain hydrochloride
  • Lidocaine HCl
  • Lidocaine hydrochloride
  • Lidocaine hydrochloride 0.1% and dextrose 5% in plastic container
  • Lidocaine hydrochloride 0.2% and dextrose 5% in plastic container
  • Lidocaine hydrochloride 0.2% in dextrose 5%
  • Lidocaine hydrochloride 0.2% in dextrose 5% in plastic container
  • Lidocaine hydrochloride 0.4% and dextrose 5% in plastic container
  • Lidocaine hydrochloride 0.4% in dextrose 5%
  • Lidocaine hydrochloride 0.4% in dextrose 5% in plastic container
  • Lidocaine hydrochloride 0.8% and dextrose 5% in plastic container
  • Lidocaine hydrochloride 0.8% in dextrose 5% in plastic container
  • Lidocaine hydrochloride 5% and dextrose 7.5%
  • Lidocaine hydrochloride in plastic container
  • Lidocaine hydrochloride preservative free
  • Lidocaine hydrochloride preservative free in plastic container
  • Lidocaine hydrochloride viscous
  • Lidocaine Viscous
  • Lidocaton
  • Lidopen
  • Lidothesin
  • Lidothesin hydrochloride
  • Lignocaine hydrochloride
  • Lta II kit
  • N-(Diethylaminoacetyl)-2,6-dimethylaniline hydrochloride
  • NSC 757420
  • omega-Diethylamino-2,6-dimethylacetanilide hydrochloride
  • Pediatric LTA kit
  • Rucaina hydrochloride
  • S 202
  • UNII-EC2CNF7XFP
  • V 262
  • Xilina hydrochloride
  • Xycaine hydrochloride
  • Xylestesin hydrochloride
  • Xylocaine
  • Xylocaine 1.5% w/ dextrose 7.5%
  • Xylocaine 4% preservative free
  • Xylocaine 5% w/ glucose 7.5%
  • Xylocaine hydrochloride
  • Xylocaine preservative free
  • Xylocaine viscous
  • Xylocard
  • Xylocitin hydrochloride
  • Xyloneural
  • Xylotox
  • Xylotox hydrochloride
  • Zingo

Systematic Names

  • 2',6'-Acetoxylidide, 2-(diethylamino)-, hydrochloride
  • 2',6'-Acetoxylidide, 2-(diethylamino)-, monohydrochloride
  • Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)
  • Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride
  • Lidocaine hydrochloride

Registry Numbers

CAS Registry Number

  • 73-78-9

FDA UNII

  • EC2CNF7XFP

Related Registry Number

  • 137-58-6 (Parent)

System Generated Number

  • 0000073789

Molecular Formulas

Molecular Formula

  • C14-H22-N2-O.Cl-H

Molecular Formula Fragments

  • C14-H22-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H

InChIKey

IYBQHJMYDGVZRY-UHFFFAOYSA-N

Smiles

Cl.CCN(CC)CC(=O)Nc1c(C)cccc1C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 60mg/kg/1H (60mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Journal of Toxicology, Clinical Toxicology. Vol. 24, Pg. 51, 1986.
dog LDLo intravenous 65700ug/kg (65.7mg/kg)   Journal de Pharmacologie. Vol. 2, Pg. 240, 1971.
frog LD50 parenteral 159mg/kg (159mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 289, Pg. 278, 1987.
guinea pig LD50 intravenous 24500ug/kg (24.5mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.
infant TDLo intravenous 10mg/kg (10mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Journal of Toxicology, Clinical Toxicology. Vol. 28, Pg. 101, 1990.
infant TDLo oral 1600ug/kg/9H- (1.6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Annals of Emergency Medicine. Vol. 17, Pg. 725, 1988.
infant TDLo oral 1632mg/kg/1W- (1632mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Clinical Pediatrics Vol. 22, Pg. 190, 1983.
man TDLo implant 5714ug/kg (5.714mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Canadian Medical Association Journal. Vol. 137, Pg. 219, 1987.
man TDLo intravenous 7143ug/kg (7.143mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP Chest. Vol. 61, Pg. 682, 1972.
man TDLo intravenous 9mg/kg/4H-C (9mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION Drug Intelligence and Clinical Pharmacy. Vol. 19, Pg. 669, 1985.
mouse LD50 intramuscular 177mg/kg (177mg/kg)   Drug Development Research. Vol. 21, Pg. 277, 1990.
mouse LD50 intraperitoneal 63mg/kg (63mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 274, Pg. 253, 1985.
mouse LD50 intravenous 15mg/kg (15mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Journal of Pharmacy and Pharmacology. Vol. 14, Pg. 48T, 1962.
mouse LD50 oral 220mg/kg (220mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970.
mouse LD50 subcutaneous 163mg/kg (163mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 103, Pg. 353, 1960.
rabbit LD50 intratracheal 28mg/kg (28mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972.
rabbit LD50 intravenous 25600ug/kg (25.6mg/kg)   Drugs in Japan Vol. 6, Pg. 879, 1982.
rat LD50 intraperitoneal 122mg/kg (122mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 111, Pg. 224, 1954.
rat LD50 intravenous 21mg/kg (21mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970.
rat LD50 subcutaneous 570mg/kg (570mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970.