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Substance Name: Repirinast [USAN:INN:JAN]
RN: 73080-51-0
UNII: 4K8KA8B61G
InChIKey: NFQIAEMCQGTTIR-UHFFFAOYSA-N

Molecular Formula

  • C20-H21-N-O5

Molecular Weight

  • 355.388
 

Classification Codes

  • Anti-Allergic
  • Anti-Allergic Agent
  • Anti-Asthmatic
  • Anti-Asthmatic Agent
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Immunologic Factors
  • Immunosuppressive Agents
  • Neurotransmitter Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Repirinast
  • Repirinast [USAN:INN:JAN]

Synonyms

  • 4H-Pyrano(3,2-c)quinoline-2-carboxylic acid, 5,6-dihydro-7,8-dimethyl-4,5-dioxo-, 3-methylbutyl ester
  • BRN 4267921
  • Isoamyl 5,6-dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano(3,2-c)quinoline-2-carboxylate
  • Isopentyl 5,6-dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano(3,2-c)quinoline-2-carboxylate
  • MY-5116
  • Repirinast
  • Repirinastum
  • Repirinastum [INN-Latin]
  • Romet
  • UNII-4K8KA8B61G

Systematic Names

  • 4H-Pyrano(3,2-c)quinoline-2-carboxylic acid, 5,6-dihydro-7,8-dimethyl-4,5-dioxo-, 3-methylbutyl ester
  • 4H-Pyrano(3,2-c)quinoline-2-carboxylic acid, 5,6-dihydro-7,8-dimethyl-4,5-dioxo-, isopentyl ester

Registry Numbers

CAS Registry Number

  • 73080-51-0

FDA UNII

  • 4K8KA8B61G

System Generated Number

  • 0073080510

Structure Descriptors

InChI

1S/C20H21NO5/c1-10(2)7-8-25-20(24)15-9-14(22)16-18(26-15)13-6-5-11(3)12(4)17(13)21-19(16)23/h5-6,9-10H,7-8H2,1-4H3,(H,21,23)

InChIKey

NFQIAEMCQGTTIR-UHFFFAOYSA-N

Smiles

c12c3c([nH]c(c1c(cc(o2)C(OCCC(C)C)=O)=O)=O)c(c(C)cc3)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 577, 1986.
mouse LD50 intraperitoneal 1435mg/kg (1435mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: PERITONITIS
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
mouse LD50 oral > 5gm/kg (5000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
rabbit LDLo oral > 5gm/kg (5000mg/kg) KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI

BLOOD: CHANGES IN SPLEEN

LIVER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
rat LD50 intraperitoneal 2783mg/kg (2783mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: PERITONITIS
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
rat LD50 oral > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
rat LD50 oral > 5gm/kg (5000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 545, 1986.