|
|
Substance Name: 3'-Deamino-3'-hydroxydoxorubicin
RN: 73113-90-3
UNII: M61CNW3494
InChIKey: HEQRYQONNHFDHG-TZSSRYMLSA-N
Note
- Substitution of the basic amino group at the C-3' of doxorubicin by a hydroxyl group overcomes recognition of the multidrug resistant P-glycoprotein and limits cardiotoxicity.
Molecular Formula
- C27-H28-O12
Molecular Weight
- 544.5062
Classification Codes
- Antineoplastic Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitors
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- 3'-Deamino-3'-hydroxydoxorubicin
Synonyms
- BRN 5205491
- Hydroxydoxorubicin
- Hydroxyrubicin
- UNII-M61CNW3494
Systematic Names
- 5,12-Naphthacenedione, 10-((2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-(hydroxyacetyl)-1-methoxy-6,8,11-trihydroxy-, (8S-cis)-
Registry Numbers
CAS Registry Number
- 73113-90-3
FDA UNII
- M61CNW3494
System Generated Number
- 0073113903
Structure Descriptors
InChI
1S/C27H28O12/c1-10-22(31)13(29)6-17(38-10)39-15-8-27(36,16(30)9-28)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,28-29,31,33,35-36H,6-9H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1InChIKey
HEQRYQONNHFDHG-TZSSRYMLSA-NSmiles
COc1cccc2C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 79mg/kg (79mg/kg) | Anti-Cancer Drugs. Vol. 4, Pg. 37, 1993. |