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Substance Name: Apraclonidine hydrochloride [USAN:USP]
RN: 73218-79-8
UNII: D2VW67N38H
InChIKey: OTQYGBJVDRBCHC-UHFFFAOYSA-N

Classification Codes

  • Adrenergic (alpha2-Agonist)
  • Adrenergic Agents
  • Drug / Therapeutic Agent

Molecular Formula

  • C9-H10-Cl2-N4.Cl-H

Molecular Weight

  • 281.573
 

Names and Synonyms

Name of Substance

  • Apraclonidine
  • Apraclonidine hydrochloride [USAN:USP]

Synonyms

  • 2,6-Dichloro-N(sup 1)-(2-imidazolidinylidene)-1,4-benzenediamine hydrochloride
  • 2,6-Dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine monohydrochloride
  • 2-((4-Amino-2,6-dichlorophenyl)imino)imidazolidine monohydrochloride
  • 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine hydrochloride
  • 3,5-Dichloro-4-(2-imidazolidinylidenimino)aniline hydrochloride
  • AL02145
  • ALO-2145
  • Apraclonidine HCl
  • Apraclonidine hydrochloride
  • Iopidine
  • Iopidine ophthalmic solution
  • NC 14 hydrochloride
  • p-Aminoclonidine hydrochloride
  • UNII-D2VW67N38H

Systematic Names

  • 1,4-Benzenediamine, 2,6-dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride
  • 1,4-Benzenediamine, 2,6-dichloro-N(sup 1)-2-imidazolidinylidene-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 73218-79-8

FDA UNII

  • D2VW67N38H

Other Registry Number

  • 87913-86-8

System Generated Number

  • 0073218798

Molecular Formulas

Molecular Formula

  • C9-H10-Cl2-N4.Cl-H

Molecular Formula Fragments

  • C9-H10-Cl2-N4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H

InChIKey

OTQYGBJVDRBCHC-UHFFFAOYSA-N

Smiles

c1(c(cc(N)cc1Cl)Cl)NC1=NCCN1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 6mg/kg (6mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 557, 1988.
mouse LD50 oral 3mg/kg (3mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 557, 1988.
rat LD50 intravenous 9mg/kg (9mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 557, 1988.
rat LD50 oral 38mg/kg (38mg/kg)   Medicamentos de Actualidad. Vol. 24, Pg. 557, 1988.