Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Diazepinomicin
RN: 733035-26-2
UNII: YPH994Y0RF
InChIKey: SALVHVNECODMJP-GNUCVDFRSA-N

Note

  • An alkaloid from the culture of a marine actinomycete of the genus Micromonospora

    NCI: A small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Diazepinomicin binds to and inhibits Ras kinase, thereby preventing the phosphorylation and activation of proteins downstream of the Ras signal transduction pathway, including serine/threonine kinase RAF (BRAF) and extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK-2). This agent also selectively binds to the peripheral benzodiazepine receptor (PBR), a receptor highly expressed in certain tumor cell types cells, inducing cell cycle arrest and apoptosis in PBR-expressing cells. Diazepinomicin can cross the blood-brain barrier (BBB). (NCI Thesaurus)

Molecular Weight

  • 462.5866
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Diazepinomicin

Synonyms

  • 11H-Dibenzo(b,E)(1,4)diazepin-11-one, 5,10-dihydro-4,6,8-trihydroxy-10-((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-
  • BU-4664L
  • ECO 4601
  • ECO-4601
  • TLN 4601
  • TLN-4601
  • UNII-YPH994Y0RF

Registry Numbers

CAS Registry Number

  • 733035-26-2

FDA UNII

  • YPH994Y0RF

Other Registry Number

  • 179981-40-9

System Generated Number

  • 0733035262

Structure Descriptors

InChI

1S/C28H34N2O4/c1-18(2)8-5-9-19(3)10-6-11-20(4)14-15-30-23-16-21(31)17-25(33)27(23)29-26-22(28(30)34)12-7-13-24(26)32/h7-8,10,12-14,16-17,29,31-33H,5-6,9,11,15H2,1-4H3/b19-10+,20-14+

InChIKey

SALVHVNECODMJP-GNUCVDFRSA-N

Smiles

CC(=CCC\C(=C\CC\C(=C\CN1C(=O)c2cccc(O)c2Nc3c(O)cc(O)cc13)\C)\C)C