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Substance Name: Sulmazole [INN]
RN: 73384-60-8
UNII: HK56EH9K44
InChIKey: XMFCOYRWYYXZMY-UHFFFAOYSA-N

Classification Codes

  • Cardiotonic Agents
  • Cardiovascular Agents
  • Enzyme Inhibitors
  • Phosphodiesterase Inhibitors
  • Protective Agents

Molecular Formula

  • C14-H13-N3-O2-S

Molecular Weight

  • 287.3417
 
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Names and Synonyms

Name of Substance

  • Sulmazole
  • Sulmazole [INN]

Synonyms

  • 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-1H-imidazo(4,5-b)pyridine
  • 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-3H-imidazo(4,5-b)pyridine
  • AR-L 115-BS
  • AR-L 115BS
  • BRN 0818370
  • EINECS 277-406-1
  • Sulmarin
  • Sulmazol
  • Sulmazol [INN-Spanish]
  • Sulmazole
  • Sulmazolum
  • Sulmazolum [INN-Latin]
  • UNII-HK56EH9K44
  • Vardax

Systematic Names

  • 1H-Imidazo(4,5-b)pyridine, 2-(2-methoxy-4-(methylsulfinyl)phenyl)-
  • Sulmazole

Registry Numbers

CAS Registry Number

  • 73384-60-8

FDA UNII

  • HK56EH9K44

Other Registry Number

  • 112363-11-8

System Generated Number

  • 0073384608

Structure Descriptors

InChI

1S/C14H13N3O2S/c1-19-12-8-9(20(2)18)5-6-10(12)13-16-11-4-3-7-15-14(11)17-13/h3-8H,1-2H3,(H,15,16,17)

InChIKey

XMFCOYRWYYXZMY-UHFFFAOYSA-N

Smiles

COc1cc(ccc1c2nc3ncccc3[nH]2)S(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 226, 1981.
dog LD50 oral 300mg/kg (300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 226, 1981.
guinea pig LD50 oral 250mg/kg (250mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 226, 1981.
mouse LD50 intravenous 163mg/kg (163mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ANTIPSYCHOTIC
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 141, 1981.
mouse LD50 oral 560mg/kg (560mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ANTIPSYCHOTIC
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 141, 1981.
rat LD50 intravenous 91mg/kg (91mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 226, 1981.
rat LD50 oral 315mg/kg (315mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 226, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 203-205 deg C   EXP
log P (octanol-water) 1.18 (none)   EXP
Water Solubility 1430 mg/L 25 EST
Vapor Pressure 9.87E-12 mm Hg 25 EST
Henry's Law Constant 4.01E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.28E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.