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Substance Name: Xylazine [USP:INN:BAN]
RN: 7361-61-7
UNII: 2KFG9TP5V8
InChIKey: BPICBUSOMSTKRF-UHFFFAOYSA-N
Note
- An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.
Molecular Formula
- C12-H16-N2-S
Molecular Weight
- 220.338
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-2 Receptor Agonists
- Adrenergic alpha-Agonists
- Analgesics
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Hypnotics and Sedatives
- Muscle Relaxants, Central
- Neuromuscular Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Xylazine
- Xylazine [USP:INN:BAN]
MeSH Heading
- Xylazine
Synonyms
- 2,6-Xylidine, N-(5,6-dihydro-4H-1,3-thiazinyl)-
- 2-(2,6-Dimethylanilino)-5,6-dihydro-4H-1,3-thiazine
- 2-(2,6-Dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine
- 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-
- 5,6-Dihydro-2-(2,6-xylidino)-4H-1,3-thiazine
- Anased
- BAY 1470
- EINECS 230-902-1
- N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
- Primazine
- Rometar
- Sedomin
- UNII-2KFG9TP5V8
- WH 7286
- Xilazina
- Xilazina [INN-Spanish]
- Xylazine
- Xylazinum
- Xylazinum [INN-Latin]
Systematic Names
- 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-
- 4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)-
- 4H-1,3-Thiazine-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro- (9CI)
- Xylazine
Registry Numbers
CAS Registry Number
- 7361-61-7
FDA UNII
- 2KFG9TP5V8
Other Registry Number
- 29335-81-7
Related Registry Number
- 23076-35-9 (mono-hydrochloride)
System Generated Number
- 0007361617
Structure Descriptors
InChI
InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)InChIKey
BPICBUSOMSTKRF-UHFFFAOYSA-NSmiles
Cc1cccc(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 18mg/kg (18mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#10054, | |
mouse | LD50 | oral | 240mg/kg (240mg/kg) | Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968. | |
mouse | LD50 | subcutaneous | 121mg/kg (121mg/kg) | Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968. | |
rat | LD50 | oral | 130mg/kg (130mg/kg) | Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968. | |
women | TDLo | intramuscular | 734ug/kg (0.734mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | American Journal of Emergency Medicine. Vol. 4, Pg. 222, 1986. |
women | TDLo | intramuscular | 22mg/kg (22mg/kg) | LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | American Journal of Emergency Medicine. Vol. 4, Pg. 222, 1986. |
women | TDLo | oral | 8mg/kg (8mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: PULSE RATE | Clinical Toxicology. Vol. 18, Pg. 663, 1981. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 140 | deg C | EXP | |
log P (octanol-water) | 4.520 | (none) | EST | |
Atmospheric OH Rate Constant | 7.76E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.