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Substance Name: Xylazine [USP:INN:BAN]
RN: 7361-61-7
UNII: 2KFG9TP5V8
InChIKey: BPICBUSOMSTKRF-UHFFFAOYSA-N

Note

  • An adrenergic alpha-2 agonist used as a sedative, analgesic and centrally acting muscle relaxant in VETERINARY MEDICINE.

Molecular Formula

  • C12-H16-N2-S

Molecular Weight

  • 220.338
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-2 Receptor Agonists
  • Adrenergic alpha-Agonists
  • Analgesics
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Hypnotics and Sedatives
  • Muscle Relaxants, Central
  • Neuromuscular Agents
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Xylazine
  • Xylazine [USP:INN:BAN]

MeSH Heading

  • Xylazine

Synonyms

  • 2,6-Xylidine, N-(5,6-dihydro-4H-1,3-thiazinyl)-
  • 2-(2,6-Dimethylanilino)-5,6-dihydro-4H-1,3-thiazine
  • 2-(2,6-Dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine
  • 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-
  • 5,6-Dihydro-2-(2,6-xylidino)-4H-1,3-thiazine
  • Anased
  • BAY 1470
  • EINECS 230-902-1
  • N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
  • Primazine
  • Rometar
  • Sedomin
  • UNII-2KFG9TP5V8
  • WH 7286
  • Xilazina
  • Xilazina [INN-Spanish]
  • Xylazine
  • Xylazinum
  • Xylazinum [INN-Latin]

Systematic Names

  • 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-
  • 4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)-
  • 4H-1,3-Thiazine-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro- (9CI)
  • Xylazine

Registry Numbers

CAS Registry Number

  • 7361-61-7

FDA UNII

  • 2KFG9TP5V8

Other Registry Number

  • 29335-81-7

Related Registry Number

  • 23076-35-9 (mono-hydrochloride)

System Generated Number

  • 0007361617

Structure Descriptors

InChI

1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)

InChIKey

BPICBUSOMSTKRF-UHFFFAOYSA-N

Smiles

c1(NC2=NCCCS2)c(cccc1C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 18mg/kg (18mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#10054,
mouse LD50 oral 240mg/kg (240mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
mouse LD50 subcutaneous 121mg/kg (121mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
rat LD50 oral 130mg/kg (130mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
women TDLo intramuscular 734ug/kg (0.734mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Emergency Medicine. Vol. 4, Pg. 222, 1986.
women TDLo intramuscular 22mg/kg (22mg/kg) LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

CARDIAC: PULSE RATE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
American Journal of Emergency Medicine. Vol. 4, Pg. 222, 1986.
women TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: PULSE RATE
Clinical Toxicology. Vol. 18, Pg. 663, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 140 deg C   EXP
log P (octanol-water) 4.520 (none)   EST
Atmospheric OH Rate Constant 7.76E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.