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Substance Name: Diatrizoate sodium [USP]
RN: 737-31-5
UNII: V5403H8VG7
InChIKey: ZEYOIOAKZLALAP-UHFFFAOYSA-M

Notes

  • A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
  • Used for separating mononuclear & other cells.

Molecular Formula

  • C11-H9-I3-N2-O4.Na

Molecular Weight

  • 635.8842
 

Classification Codes

  • Diagnostic Aid (Radiopaque Medium)
  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Diatrizoate sodium [USP]
  • Histopaque
  • Sodium amidotrizoate [INN]

Synonyms

  • 3,5-Diacetamido-2,4,6-triiodobenzoic acid, sodium salt
  • 3,5-Diacetylamino-2,4,6-trijodbenzosaeure natrium
  • 3,5-Diacetylamino-2,4,6-trijodbenzosaeure natrium [German]
  • Amidotrizoate de sodium
  • Amidotrizoate de sodium [INN-French]
  • Amidotrizoato sodico
  • Amidotrizoato sodico [INN-Spanish]
  • Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, sodium salt
  • Conray 35
  • Diatrizoate sodium
  • Diatrizoate sodium salt
  • Diatrizoic acid sodium salt
  • EINECS 212-004-1
  • Hpaque - cysto
  • HSDB 8078
  • Hypaque
  • Hypaque 50
  • Hypaque Cysto
  • Hypaque sodium
  • Hypaque sodium 20%
  • Hypaque-DIU
  • Iothalamate
  • Md
  • MD 50
  • MD-50
  • Ml 216
  • Monosodium 3,5-diacetamido-2,4,6-triiodobenzoate
  • Natrii amidotrizoas
  • Natrii amidotrizoas [INN-Latin]
  • NSC 61815
  • Radioselectan
  • Renografin 76 Injectable (Veterinary)
  • Sodium 3,5-diacetamido-2,4,6-triiodobenzoate
  • Sodium amidotrizoate
  • Sodium diacetyldiaminetriiodobenzoate
  • Sodium diatrizoate
  • Sodium Diatrizoate [BAN]
  • Triombrin
  • Triombrine
  • UNII-V5403H8VG7
  • Urografic acid, sodium salt
  • Urovist 300
  • Urovist Sodium
  • Urovist Sodium 300
  • Vascoray
  • WIN 8308-3

Systematic Names

  • Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt
  • Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, monosodium salt
  • Sodium amidotrizoate

Mixture Name

  • Gastrografin

Registry Numbers

CAS Registry Number

  • 737-31-5

FDA UNII

  • V5403H8VG7

System Generated Number

  • 0000737315

Molecular Formulas

Molecular Formula

  • C11-H9-I3-N2-O4.Na

Molecular Formula Fragments

  • C11-H9-I3-N2-O4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1

InChIKey

ZEYOIOAKZLALAP-UHFFFAOYSA-M

Smiles

[Na+].CC(=O)Nc1c(I)c(NC(=O)C)c(I)c(C(=O)[O-])c1I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 11300mg/kg (11300mg/kg)   Compilation of LD50 Values of New Drugs.
dog LD50 intravenous 13200mg/kg (13200mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 394, 1956.
mouse LD50 intramuscular 20349mg/kg (20349mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 307, 1956.
mouse LD50 intraperitoneal > 5gm/kg (5000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toksikologicheskii Vestnik. Vol. (3), Pg. 46, 1994.
mouse LD50 intravenous 14gm/kg (14000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 394, 1956.
mouse LD50 oral > 7gm/kg (7000mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toksikologicheskii Vestnik. Vol. (3), Pg. 46, 1994.
rabbit LD50 intravenous 12200mg/kg (12200mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 394, 1956.
rat LD50 intraperitoneal > 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toksikologicheskii Vestnik. Vol. (3), Pg. 46, 1994.
rat LD50 intravenous 11400mg/kg (11400mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 394, 1956.
rat LD50 oral > 7gm/kg (7000mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toksikologicheskii Vestnik. Vol. (3), Pg. 46, 1994.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 261 deg C   EXP
log P (octanol-water) -1.280 (none)   EST
Water Solubility 6.00E+05 mg/L 20 EXP
Atmospheric OH Rate Constant 1.41E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.