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Substance Name: Tripamide [USAN:INN:JAN]
RN: 73803-48-2
UNII: G36A0E9CVT
InChIKey: UHLOVGKIEARANS-NIFPGPBJSA-N

Classification Codes

  • Antihypertensive
  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Natriuretic Agents
  • Reproductive Effect
  • Sodium Potassium Chloride Symporter Inhibitors

Molecular Formula

  • C16-H20-Cl-N3-O3-S

Molecular Weight

  • 369.871
 
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Names and Synonyms

Name of Substance

  • Tripamide
  • Tripamide [USAN:INN:JAN]

Synonyms

  • 4-Chlor-N-(endo-perhydro-4,7-methano-2-isoindolyl)-3-sulfamoylbenzamid
  • 4-Chloro-N-(endo-hexahydro-4,7-methanoisoindolin-2-yl)-3-sulfamoylbenzamide
  • 5-20-05-00123 (Beilstein Handbook Reference)
  • ADR 033
  • ADR-033
  • BRN 1663663
  • E 614
  • E-614
  • endo-4-Chloro-N-(hexahydro-4,7-methanoisoindol-2-yl)-3-sulfamoylbenzamide
  • N-(4-Aza-endo-tricyclo(5.2.1.5(sup 2,6))-decan-4-yl)-4-chloro-3-sulfamoylbenzamide
  • Normonal
  • TDS (diuretic)
  • Tripamida
  • Tripamida [INN-Spanish]
  • Tripamide
  • Tripamidum
  • Tripamidum [INN-Latin]
  • UNII-G36A0E9CVT

Systematic Name

  • Benzamide, 3-(aminosulfonyl)-4-chloro-N-(octahydro-4,7-methano-2H-isoindol-2-yl)-, (3aalpha,4alpha,7alpha,7aalpha)-

Registry Numbers

CAS Registry Number

  • 73803-48-2

FDA UNII

  • G36A0E9CVT

Other Registry Number

  • 92308-33-3

System Generated Number

  • 0073803482

Structure Descriptors

InChI

1S/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12-,13+

InChIKey

UHLOVGKIEARANS-NIFPGPBJSA-N

Smiles

NS(=O)(=O)c1cc(ccc1Cl)C(=O)NN2C[C@@H]3[C@@H]4CC[C@@H](C4)[C@@H]3C2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
mouse LD50 intramuscular > 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
mouse LD50 intraperitoneal > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
mouse LD50 subcutaneous > 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
rat LD50 intramuscular > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
rat LD50 intraperitoneal > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
rat LD50 oral > 8gm/kg (8000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-15, 1982.