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Substance Name: trans-Tramadol hydrochloride
RN: 73806-49-2
UNII: 5S5NK3Y57M
InChIKey: PPKXEPBICJTCRU-DMLYUBSXSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H25-N-O2.Cl-H

Molecular Weight

  • 299.8394
 
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Names and Synonyms

Results Name

  • trans-Tramadol hydrochloride

Name of Substance

  • Tramadol hydrochloride, trans-

Synonyms

  • Crispin
  • K-315
  • trans-Tramadol HCl
  • trans-Tramadol hydrochloride
  • UNII-5S5NK3Y57M

Systematic Names

  • Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, hydrochloride, (1R,2S)-rel-
  • Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, hydrochloride, trans-
  • Cyclohexanol, 2-((dimethylamino)methyl)-1-(m-methoxyphenyl)-, hydrochloride, (E)-

Registry Numbers

CAS Registry Number

  • 73806-49-2

FDA UNII

  • 5S5NK3Y57M

System Generated Number

  • 0073806492

Molecular Formulas

Molecular Formula

  • C16-H25-N-O2.Cl-H

Molecular Formula Fragments

  • C16-H25-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16-;/m0./s1

InChIKey

PPKXEPBICJTCRU-DMLYUBSXSA-N

Smiles

CN(C)C[C@@H]1CCCC[C@@]1(c2cccc(c2)OC)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 50mg/kg (50mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
dog LD50 oral 450mg/kg (450mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
dog LDLo intramuscular 100mg/kg (100mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
guinea pig LD50 oral 850mg/kg (850mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
guinea pig LD50 subcutaneous 245mg/kg (245mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
mouse LD50 intramuscular 258mg/kg (258mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1427, 1972.
mouse LD50 intravenous 60450ug/kg (60.45mg/kg)   Collection of Czechoslovak Chemical Communications. Vol. 52, Pg. 1340, 1987.
mouse LD50 oral 270mg/kg (270mg/kg) BEHAVIORAL: ANALGESIA Collection of Czechoslovak Chemical Communications. Vol. 52, Pg. 1340, 1987.
mouse LD50 subcutaneous 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
rabbit LD50 oral 500mg/kg (500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
rabbit LDLo intramuscular 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
rabbit LDLo intravenous 50mg/kg (50mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
rat LD50 intramuscular 244mg/kg (244mg/kg)   Drugs in Japan Vol. 6, Pg. 513, 1982.
rat LD50 intravenous 57600ug/kg (57.6mg/kg)   Drugs in Japan Vol. 6, Pg. 513, 1982.
rat LD50 oral 228mg/kg (228mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.
rat LD50 subcutaneous 286mg/kg (286mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 164, 1978.