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Substance Name: Cilostazol [USAN:USP:INN:BAN:JAN]
RN: 73963-72-1
UNII: N7Z035406B
InChIKey: RRGUKTPIGVIEKM-UHFFFAOYSA-N

Note

  • Daily Med: Cilostazol is a quinolinone derivative that inhibits cellular phosphodiesterase (more specific for phosphodiesterase III).

Molecular Formula

  • C20-H27-N5-O2

Molecular Weight

  • 369.4663
 

Classification Codes

  • Anti-Asthmatic Agents
  • Antithrombotic
  • Autonomic Agents
  • Bronchodilator Agents
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Human Data
  • Inhibitor (Platelet)
  • Neuroprotective Agents
  • Peripheral Nervous System Agents
  • Phosphodiesterase 3 Inhibitors
  • Phosphodiesterase Inhibitors
  • Platelet Aggregation Inhibitors
  • Protective Agents
  • Reproductive Effect
  • Respiratory System Agents
  • Vasodilator
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Cilostazol
  • Cilostazol [USAN:USP:INN:BAN:JAN]

Synonyms

  • 3,4-Dihydro-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-2(1H)-quinolinone
  • 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone
  • 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril
  • BRN 3632107
  • Cilostazol
  • Cilostazole
  • Cilostazolum
  • Cilostazolum [INN-Latin]
  • HSDB 8312
  • OPC 13013
  • OPC 21
  • OPC-13013
  • OPC-21
  • Pletaal
  • Pletal
  • UNII-N7Z035406B

Systematic Names

  • 2(1H)-Quinolinone, 3,4-dihydro-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-
  • 2(1H)-Quionlinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-
  • 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril

Registry Numbers

CAS Registry Number

  • 73963-72-1

FDA UNII

  • N7Z035406B

Other Registry Number

  • 89332-50-3

System Generated Number

  • 0073963721

Structure Descriptors

InChI

1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)

InChIKey

RRGUKTPIGVIEKM-UHFFFAOYSA-N

Smiles

O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 504, 1990.
man TDLo oral 1248ug/kg (1.248mg/kg) BEHAVIORAL: HEADACHE Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1173, 1985.
mouse LD50 intramuscular > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 504, 1990.
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 504, 1990.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 504, 1990.
rat LD50 intramuscular > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 504, 1990.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 504, 1990.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 504, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 160 deg C   EXP
log P (octanol-water) 4.040 (none)   EST
Atmospheric OH Rate Constant 5.63E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.