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Substance Name: Azapropazone sodium
RN: 74037-31-3
InChIKey: HMSQKVVNPJTJHU-UHFFFAOYSA-N

Note

  • An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formulas

  • C16-H19-N4-O2.Na
  • C16-H20-N4-O2.Na

Molecular Weight

  • 323.35
 
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Names and Synonyms

Results Name

  • Azapropazone sodium

Synonyms

  • 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine sodium salt
  • 3-Dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine sodium salt
  • Azapropazon natriumsalz
  • Azapropazon natriumsalz [German]
  • Azapropazone sodium
  • MI 85-Natriumsalz
  • MI 85-Natriumsalz [German]
  • MI-85 sodium
  • Sodium azapropazone

Systematic Name

  • 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, sodium salt

Registry Numbers

CAS Registry Number

  • 74037-31-3

System Generated Number

  • 0074037313

Molecular Formulas

Molecular Formulas

  • C16-H19-N4-O2.Na
  • C16-H20-N4-O2.Na

Molecular Formula Fragments

  • C16-H19-N4-O2
  • C16-H20-N4-O2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C16H20N4O2.Na/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22;/h7-9,11H,5-6H2,1-4H3;/q;+1

InChIKey

HMSQKVVNPJTJHU-UHFFFAOYSA-N

Smiles

CCCC1C(=O)N2c3cc(ccc3N=C(N2C1=O)N(C)C)C.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 4gm/kg (4000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
mouse LD50 intravenous 960mg/kg (960mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
mouse LD50 oral 1950mg/kg (1950mg/kg)   Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
rat LD50 intravenous 810mg/kg (810mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
rat LD50 oral 1900mg/kg (1900mg/kg) GASTROINTESTINAL: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.