Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Haloperidol decanoate [USAN:USP:BAN:JAN]
RN: 74050-97-8
UNII: AC20PJ4101
InChIKey: GUTXTARXLVFHDK-UHFFFAOYSA-N

Note

  • A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in MENTAL RETARDATION and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)/Haloperidol/

Molecular Formula

  • C31-H41-Cl-F-N-O3

Molecular Weight

  • 530.12
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Human Data
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Haloperidol decanoate
  • Haloperidol decanoate [USAN:USP:BAN:JAN]

Synonyms

  • Decanoic acid, 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl ester
  • Decanoic acid, ester with 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
  • Depot haloperidol
  • EINECS 277-679-7
  • Haldol
  • Haldol decanoas
  • Haldol decanoate
  • Halomonth
  • Haloperidol decanoate
  • Haloperidol depot
  • KD 136
  • KD 16
  • KD-136
  • Neoperidole
  • R 13,672
  • R 13672
  • R-13,672
  • UNII-AC20PJ4101

Systematic Names

  • 4-(4-Chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidyl decanoate
  • Decanoic acid, 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl ester

Registry Numbers

CAS Registry Number

  • 74050-97-8

FDA UNII

  • AC20PJ4101

Other Registry Number

  • 77129-05-6

System Generated Number

  • 0074050978

Structure Descriptors

InChI

1S/C31H41ClFNO3/c1-2-3-4-5-6-7-8-11-30(36)37-31(26-14-16-27(32)17-15-26)20-23-34(24-21-31)22-9-10-29(35)25-12-18-28(33)19-13-25/h12-19H,2-11,20-24H2,1H3

InChIKey

GUTXTARXLVFHDK-UHFFFAOYSA-N

Smiles

C1(c2ccc(Cl)cc2)(CCN(CCCC(c2ccc(F)cc2)=O)CC1)OC(CCCCCCCCC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular > 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
mouse LD50 intramuscular > 3500mg/kg (3500mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
mouse LD50 intraperitoneal 288mg/kg (288mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
mouse LD50 oral 739mg/kg (739mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
mouse LD50 subcutaneous 1990mg/kg (1990mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
rat LD50 intramuscular > 1525mg/kg (1525mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
rat LD50 intraperitoneal 328mg/kg (328mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
rat LD50 oral 1717mg/kg (1717mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
rat LD50 subcutaneous 780mg/kg (780mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6731, 1985.
women TDLo intravenous 11600ug/kg/4D (11.6mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

CARDIAC: CHANGE IN RATE
Annals of Internal Medicine. Vol. 119, Pg. 391, 1993.