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Substance Name: Ketorolac [INN:BAN]
RN: 74103-06-3
UNII: YZI5105V0L
InChIKey: OZWKMVRBQXNZKK-UHFFFAOYSA-N

Note

  • A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)

Molecular Formula

  • C15-H13-N-O3

Molecular Weight

  • 255.272
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Cyclooxygenase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Peripheral Nervous System Agents
  • Sensory System Agents

Names and Synonyms

Name of Substance

  • Ketorolac
  • Ketorolac [INN:BAN]

MeSH Heading

  • Ketorolac

Synonyms

  • (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • (+-)-Ketorolac
  • Acular LS
  • Ketorolac
  • Ketorolaco
  • Ketorolaco [Spanish]
  • Ketorolacum
  • Ketorolacum [Latin]
  • Macril
  • RS 37619
  • UNII-YZI5105V0L

Systematic Name

  • 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)-

Registry Numbers

CAS Registry Number

  • 74103-06-3

FDA UNII

  • YZI5105V0L

Other Registry Number

  • 66635-83-4

System Generated Number

  • 0074103063

Structure Descriptors

InChI

1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)

InChIKey

OZWKMVRBQXNZKK-UHFFFAOYSA-N

Smiles

n12c([C@@H](C(O)=O)CC2)ccc1C(c1ccccc1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 200mg/kg (200mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982.
mouse LDLo intraperitoneal 100mg/kg (100mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 12, Pg. 684, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 160.5 deg C   EXP
pKa Dissociation Constant 3.49 (none)   EXP
log P (octanol-water) 2.320 (none)   EST
Atmospheric OH Rate Constant 2.03E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.