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Substance Name: Ketorolac tromethamine [USAN:USP]
RN: 74103-07-4
UNII: 4EVE5946BQ
InChIKey: BWHLPLXXIDYSNW-UHFFFAOYSA-N
Note
- A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is a non-steroidal anti-inflammatory agent used for analgesia for postoperative pain and inhibits cyclooxygenase activity.
Molecular Formula
- C15-H13-N-O3.C4-H11-N-O3
Molecular Weight
- 376.4066
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Cyclooxygenase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Peripheral Nervous System Agents
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Ketorolac tromethamine
- Ketorolac tromethamine [USAN:USP]
MeSH Heading
- Ketorolac tromethamine
Synonyms
- (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Acular
- Acular LS
- Acular PF
- Acular preservative free
- Acuvail
- Godek
- Ketorolac tromethamine
- Ketorolac tromethamine ophthalmic solution
- NSC 758637
- Sprix
- Syntex
- Toradol
- Tromethamine ketorolac
- UNII-4EVE5946BQ
Systematic Name
- 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro, (+-)-, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
Registry Numbers
CAS Registry Number
- 74103-07-4
FDA UNII
- 4EVE5946BQ
System Generated Number
- 0074103074
Molecular Formulas
Molecular Formula
- C15-H13-N-O3.C4-H11-N-O3
Molecular Formula Fragments
- C15-H13-N-O3
- C4-H11-N-O3
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2InChIKey
BWHLPLXXIDYSNW-UHFFFAOYSA-NSmiles
NC(CO)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | intramuscular | 857ug/kg (0.857mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 305, 1994. |
man | TDLo | intramuscular | 858ug/kg (0.858mg/kg) | Annals of Pharmacotherpy. Vol. 26, Pg. 1237, 1992. | |
man | TDLo | intramuscular | 858ug/kg (0.858mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Annals of Pharmacotherpy. Vol. 26, Pg. 1237, 1992. |
man | TDLo | intramuscular | 4300ug/kg/8D- (4.3mg/kg) | BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Clinical Nephrology. Vol. 44, Pg. 276, 1995. |
man | TDLo | intramuscular | 19853ug/kg/12 (19.853mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Annals of Pharmacotherpy. Vol. 27, Pg. 1055, 1993. |
mouse | LD50 | intraperitoneal | 225mg/kg (225mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999. |
mouse | LD50 | oral | 293mg/kg (293mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999. |
rat | LD50 | oral | 189mg/kg (189mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Toksikologicheskii Vestnik. Vol. (6), Pg. 41, 1999. |
women | LDLo | intramuscular | 15mg/kg/6D-I (15mg/kg) | Archives of Internal Medicine. Vol. 153, Pg. 1000, 1993. | |
women | LDLo | intramuscular | 15mg/kg/6D-I (15mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Archives of Internal Medicine. Vol. 153, Pg. 1000, 1993. |
women | TDLo | intramuscular | 600ug/kg (0.6mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS | Archives of Internal Medicine. Vol. 158, Pg. 411, 1998. |
women | TDLo | intramuscular | 1200ug/kg (1.2mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Southern Medical Journal. Vol. 87, Pg. 282, 1994. |
women | TDLo | intramuscular | 8400ug/kg/3D- (8.4mg/kg) | American Journal of Kidney Diseases. Vol. 24, Pg. 578, 1994. | |
women | TDLo | intramuscular | 8400ug/kg/3D- (8.4mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | American Journal of Kidney Diseases. Vol. 24, Pg. 578, 1994. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | -0.59 | (none) | EXP | |
Water Solubility | 1.37E+04 | mg/L | 25 | EST |
Vapor Pressure | 2.64E-21 | mm Hg | 25 | EST |
Henry's Law Constant | 3.34E-28 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.15E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.