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Substance Name: N-Deacetyl-N-formylcolchicine
RN: 7411-12-3
UNII: U02803H7OJ
InChIKey: HDSXDWASQCHADG-HNNXBMFYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H23-N-O6

Molecular Weight

  • 385.4137
 
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Names and Synonyms

Name of Substance

  • N-Deacetyl-N-formylcolchicine

Synonyms

  • 4-14-00-00942 (Beilstein Handbook Reference)
  • BRN 2824080
  • Formamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
  • Formyldescaetylcolchicine, N-
  • Gloriosine
  • N-Deacetyl-N-formylcolchicine
  • N-Formyldeacetylcolchicine
  • N-Formyldesacetylcolchicine
  • NSC 403142
  • UNII-U02803H7OJ

Systematic Names

  • Colchicine, N-deacetyl-N-formyl-
  • Formamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- (9CI)

Registry Numbers

CAS Registry Number

  • 7411-12-3

FDA UNII

  • U02803H7OJ

System Generated Number

  • 0007411123

Structure Descriptors

InChI

1S/C21H23NO6/c1-25-17-8-6-13-14(10-16(17)24)15(22-11-23)7-5-12-9-18(26-2)20(27-3)21(28-4)19(12)13/h6,8-11,15H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1

InChIKey

HDSXDWASQCHADG-HNNXBMFYSA-N

Smiles

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2666ug/kg (2.666mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 636, 1981.
mouse LD50 intravenous 9200ug/kg (9.2mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Pharmacology and Toxicology. English translation of FATOAO. Vol. 20, Pg. 284, 1957.
rat LD50 intravenous 4400ug/kg (4.4mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Pharmacology and Toxicology. English translation of FATOAO. Vol. 20, Pg. 284, 1957.
rat LDLo subcutaneous 2mg/kg (2mg/kg)   Helvetica Chimica Acta. Vol. 33, Pg. 1606, 1950.