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Substance Name: Methotrexate disodium salt
RN: 7413-34-5
UNII: 3IG1E710ZN
InChIKey: DASQOOZCTWOQPA-GXKRWWSZSA-L

Note

  • An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Molecular Formulas

  • C20-H20-N8-O5.2Na
  • C20-H22-N8-O5.2Na

Molecular Weight

  • 498.409
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Methotrexate disodium salt

Synonyms

  • 4-Amino-N(sup 10)-methylpteroylglutamic acid disodium salt
  • Abitrexate
  • Amethopterin sodium
  • Disodium methotrexate
  • EINECS 231-022-0
  • Farmitrexat
  • Folex
  • Folex PFS
  • Ledertrexate
  • Methotrexat dinatrium
  • Methotrexate disodium salt
  • Methotrexate LPF
  • Methotrexate preservative free
  • Methotrexate sodium
  • Methotrexate sodium preservative free
  • Mexate
  • Mexate-AQ
  • Mexate-AQ preserved
  • MTX disodium
  • Sodium methotrexate
  • Trexall
  • UNII-3IG1E710ZN

Systematic Names

  • Disodium N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamate
  • Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, disodium salt, L-(+)-

Registry Numbers

CAS Registry Number

  • 7413-34-5

FDA UNII

  • 3IG1E710ZN

Related Registry Number

  • 59-05-2 (Parent)

System Generated Number

  • 0007413345

Molecular Formulas

Molecular Formulas

  • C20-H20-N8-O5.2Na
  • C20-H22-N8-O5.2Na

Molecular Formula Fragments

  • C20-H20-N8-O5
  • C20-H22-N8-O5
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C20H22N8O5.2Na/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);;/q;2*+1/p-2/t13-;;/m0../s1

InChIKey

DASQOOZCTWOQPA-GXKRWWSZSA-L

Smiles

[Na+].[Na+].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 284mg/kg (284mg/kg)   Journal of the National Cancer Institute. Vol. 58, Pg. 735, 1977.