|
|
Substance Name: Etidronate disodium [USAN:USP:JAN]
RN: 7414-83-7
UNII: M16PXG993G
InChIKey: GWBBVOVXJZATQQ-UHFFFAOYSA-L
Note
- A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Molecular Formulas
- C2-H6-Na2-O7-P2
- C2-H6-O7-P2.2Na
- C2-H8-O7-P2.2Na
Molecular Weight
- 249.9904
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Bone Resorption Inhibitor
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Etidronate disodium
- Etidronate disodium [USAN:USP:JAN]
MeSH Heading
- Etidronate disodium
Synonyms
- (1-Hydroxyethane-1,1-diyl)diphosphonic acid disodium salt
- (1-Hydroxyethylidene)diphosphonic acid, disodium salt
- 1-Hydroxyethylidene-1,1-diphosphonic acid disodium salt
- Didronel
- Didronel R
- Diphos
- Disodium (1-hydroxyethylidene)diphosphonate
- Disodium 1-hydroxyethylidene phosphonate
- Disodium dihydrogen (1-hydroxyethylidene)diphosphonate
- Disodium ethane-1-hydroxy-1,1-diphosphonate
- Disodium ethanol-1,1-diphosphonate
- Disodium ethydronate
- Disodium etidronate
- EINECS 231-025-7
- Ethane-1-hydroxy-1,1-diphosphonate, disodium salt
- Ethane-1-hydroxy-1,1-diphosphonic acid, disodium salt
- Etidronate disodium
- Etidronsaeure dinatriumsalz
- NSC 759157
- SM-5600
- Sodium ethidronate
- Sodium ethydronate
- Sodium etidronate
- UNII-M16PXG993G
Systematic Names
- Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate
- Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt
- Phosphonic acid, (1-hydroxyethylidene)di-, disodium salt
- Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2)
Registry Numbers
CAS Registry Number
- 7414-83-7
FDA UNII
- M16PXG993G
Other Registry Numbers
- 1159812-97-1
- 1338481-55-2
- 187285-10-5
System Generated Number
- 0007414837
Molecular Formulas
Molecular Formulas
- C2-H6-Na2-O7-P2
- C2-H6-O7-P2.2Na
- C2-H8-O7-P2.2Na
Molecular Formula Fragments
- C2-H6-O7-P2
- C2-H8-O7-P2
- COMPONENT
- Na
Structure Descriptors
InChI
InChI=1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2InChIKey
GWBBVOVXJZATQQ-UHFFFAOYSA-LSmiles
[Na+].[Na+].CC(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 32mg/kg (32mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Journal of Pharmaceutical Sciences. Vol. 73, Pg. 1097, 1984. |
dog | LDLo | oral | 500mg/kg (500mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1257, 1989. |
mouse | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | British UK Patent Application. Vol. #2096889, | |
mouse | LD50 | intravenous | 49mg/kg (49mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989. |
mouse | LD50 | oral | 1900mg/kg (1900mg/kg) | Drugs in Japan Vol. -, Pg. 221, 1995. | |
mouse | LD50 | subcutaneous | 260mg/kg (260mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989. |
rabbit | LD50 | oral | 581mg/kg (581mg/kg) | KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Toxicology and Applied Pharmacology. Vol. 22, Pg. 661, 1972. |
rat | LD50 | intravenous | 35mg/kg (35mg/kg) | British UK Patent Application. Vol. #2096889, | |
rat | LD50 | oral | 1340mg/kg (1340mg/kg) | KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI | Toxicology and Applied Pharmacology. Vol. 22, Pg. 661, 1972. |
rat | LD50 | subcutaneous | 372mg/kg (372mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989. |
women | TDLo | oral | 240mg/kg/26W- (240mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR | Postgraduate Medical Journal. Vol. 74, Pg. 363, 1998. |
women | TDLo | oral | 240mg/kg/22W- (240mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR | Postgraduate Medical Journal. Vol. 74, Pg. 363, 1998. |
women | TDLo | oral | 588mg/kg/28W- (588mg/kg) | MUSCULOSKELETAL: OTHER CHANGES MUSCULOSKELETAL: OSTEOMALACIA | Drug Safety. Vol. 7, Pg. 162, 1992. |