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Substance Name: Etidronate disodium [USAN:USP:JAN]
RN: 7414-83-7
UNII: M16PXG993G
InChIKey: GWBBVOVXJZATQQ-UHFFFAOYSA-L

Note

  • A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.

Molecular Formulas

  • C2-H6-Na2-O7-P2
  • C2-H6-O7-P2.2Na
  • C2-H8-O7-P2.2Na

Molecular Weight

  • 249.9904
 

Classification Codes

  • Bone Resorption Inhibitor
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Etidronate disodium
  • Etidronate disodium [USAN:USP:JAN]

MeSH Heading

  • Etidronate disodium

Synonyms

  • (1-Hydroxyethane-1,1-diyl)diphosphonic acid disodium salt
  • (1-Hydroxyethylidene)diphosphonic acid, disodium salt
  • 1-Hydroxyethylidene-1,1-diphosphonic acid disodium salt
  • Didronel
  • Didronel R
  • Diphos
  • Disodium (1-hydroxyethylidene)diphosphonate
  • Disodium 1-hydroxyethylidene phosphonate
  • Disodium dihydrogen (1-hydroxyethylidene)diphosphonate
  • Disodium ethane-1-hydroxy-1,1-diphosphonate
  • Disodium ethanol-1,1-diphosphonate
  • Disodium ethydronate
  • Disodium etidronate
  • EINECS 231-025-7
  • Ethane-1-hydroxy-1,1-diphosphonate, disodium salt
  • Ethane-1-hydroxy-1,1-diphosphonic acid, disodium salt
  • Etidronate disodium
  • Etidronsaeure dinatriumsalz
  • SM-5600
  • Sodium ethidronate
  • Sodium ethydronate
  • Sodium etidronate
  • UNII-M16PXG993G

Systematic Names

  • Disodium dihydrogen (1-hydroxyethylidene)bisphosphonate
  • Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt
  • Phosphonic acid, (1-hydroxyethylidene)di-, disodium salt
  • Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-, sodium salt (1:2)

Registry Numbers

CAS Registry Number

  • 7414-83-7

FDA UNII

  • M16PXG993G

Other Registry Numbers

  • 1159812-97-1
  • 1338481-55-2
  • 187285-10-5

System Generated Number

  • 0007414837

Molecular Formulas

Molecular Formulas

  • C2-H6-Na2-O7-P2
  • C2-H6-O7-P2.2Na
  • C2-H8-O7-P2.2Na

Molecular Formula Fragments

  • C2-H6-O7-P2
  • C2-H8-O7-P2
  • COMPONENT
  • Na

Structure Descriptors

InChI

InChI=1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChIKey

GWBBVOVXJZATQQ-UHFFFAOYSA-L

Smiles

[Na+].[Na+].CC(O)(P(=O)(O)[O-])P(=O)(O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 32mg/kg (32mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Journal of Pharmaceutical Sciences. Vol. 73, Pg. 1097, 1984.
dog LDLo oral 500mg/kg (500mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1257, 1989.
mouse LD50 intraperitoneal 250mg/kg (250mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 intravenous 49mg/kg (49mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989.
mouse LD50 oral 1900mg/kg (1900mg/kg)   Drugs in Japan Vol. -, Pg. 221, 1995.
mouse LD50 subcutaneous 260mg/kg (260mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989.
rabbit LD50 oral 581mg/kg (581mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 22, Pg. 661, 1972.
rat LD50 intravenous 35mg/kg (35mg/kg)   British UK Patent Application. Vol. #2096889,
rat LD50 oral 1340mg/kg (1340mg/kg) KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI Toxicology and Applied Pharmacology. Vol. 22, Pg. 661, 1972.
rat LD50 subcutaneous 372mg/kg (372mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 1251, 1989.
women TDLo oral 240mg/kg/26W- (240mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR

SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR
Postgraduate Medical Journal. Vol. 74, Pg. 363, 1998.
women TDLo oral 240mg/kg/22W- (240mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR

SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR
Postgraduate Medical Journal. Vol. 74, Pg. 363, 1998.
women TDLo oral 588mg/kg/28W- (588mg/kg) MUSCULOSKELETAL: OTHER CHANGES

MUSCULOSKELETAL: OSTEOMALACIA
Drug Safety. Vol. 7, Pg. 162, 1992.