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Substance Name: Pimobendan [USAN:INN:BAN]
RN: 74150-27-9
UNII: 34AP3BBP9T
InChIKey: GLBJJMFZWDBELO-UHFFFAOYSA-N

Note

  • Produces arterial & venous dilatation in dogs.

Molecular Formula

  • C19-H18-N4-O2

Molecular Weight

  • 334.3772
 

Classification Codes

  • Cardiotonic
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Phosphodiesterase Inhibitors
  • Protective Agents
  • Reproductive Effect
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Pimobendan
  • Pimobendan [USAN:INN:BAN]

Synonyms

  • 6-(2-(4-Methoxyphenyl)-4,5-dihydro-1H-benzimidazol-5-yl)-5-methyl-3(2H)-pyridazinone
  • BRN 4207330
  • dl-Pimobendan
  • Pimobendan
  • Pimobendan [INN-Spanish]
  • Pimobendane
  • Pimobendane [INN-French]
  • Pimobendanum
  • Pimobendanum [INN-Latin]
  • Racemic pinobendan
  • UD-CG 115
  • UD-CG 115 BS
  • UDCG-115
  • UNII-34AP3BBP9T
  • Vetmedin

Systematic Name

  • 3(2H)-Pyridazinone, 4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-

Registry Numbers

CAS Registry Number

  • 74150-27-9

FDA UNII

  • 34AP3BBP9T

Other Registry Number

  • 118428-36-7

System Generated Number

  • 0074150279

Structure Descriptors

InChI

1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)

InChIKey

GLBJJMFZWDBELO-UHFFFAOYSA-N

Smiles

CC1CC(=O)NN=C1c2ccc3c(c2)nc([nH]3)c4ccc(cc4)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 oral > 2gm/kg (2000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992.
rat LD50 intravenous 72mg/kg (72mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992.
rat LD50 intravenous 75mg/kg (75mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992.
rat LD50 oral 950mg/kg (950mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

ENDOCRINE: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992.
rat LD50 subcutaneous > 300mg/kg (300mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 25, Pg. 815, 1994.