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Substance Name: Molindone [INN:BAN]
RN: 7416-34-4
UNII: RT3Y3QMF8N
InChIKey: KLPWJLBORRMFGK-UHFFFAOYSA-N

Note

  • An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)

Molecular Formula

  • C16-H24-N2-O2

Molecular Weight

  • 276.378
 

Classification Codes

  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Psychotropic Drugs
  • Tranquilizing Agents

Names and Synonyms

Name of Substance

  • Molindone
  • Molindone [INN:BAN]

MeSH Heading

  • Molindone

Synonyms

  • (+-)-Molindone
  • 3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one
  • 3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
  • 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-
  • HSDB 3131
  • Indol-4(5H)-one, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-
  • Molindona
  • Molindona [INN-Spanish]
  • Molindone
  • Molindonum
  • Molindonum [INN-Latin]
  • UNII-RT3Y3QMF8N

Systematic Name

  • 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-

Registry Numbers

CAS Registry Number

  • 7416-34-4

FDA UNII

  • RT3Y3QMF8N

Other Registry Number

  • 65973-37-7

Related Registry Number

  • 15622-65-8 (mono-hydrochloride)

System Generated Number

  • 0007416344

Structure Descriptors

InChI

1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3

InChIKey

KLPWJLBORRMFGK-UHFFFAOYSA-N

Smiles

C1OCCN(C1)C[C@@H]1CCc2c(C1=O)c(c([nH]2)C)CC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 714ug/kg/D (0.714mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ANTIPSYCHOTIC
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 402, 1969.
man TDLo oral 4285ug/kg/3D- (4.285mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Journal of Clinical Psychiatry. Vol. 47, Pg. 607, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 180.5 deg C   EXP
log P (octanol-water) 2.310 (none)   EST
Atmospheric OH Rate Constant 3.84E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.