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Substance Name: Molindone [INN:BAN]
RN: 7416-34-4
UNII: RT3Y3QMF8N
InChIKey: KLPWJLBORRMFGK-UHFFFAOYSA-N
Note
- An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)
Molecular Formula
- C16-H24-N2-O2
Molecular Weight
- 276.378
- All
- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Psychotropic Drugs
- Tranquilizing Agents
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Names and Synonyms
Name of Substance
- Molindone
- Molindone [INN:BAN]
MeSH Heading
- Molindone
Synonyms
- (+-)-Molindone
- 3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one
- 3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
- 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-
- HSDB 3131
- Indol-4(5H)-one, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-
- Molindona
- Molindona [INN-Spanish]
- Molindone
- Molindonum
- Molindonum [INN-Latin]
- UNII-RT3Y3QMF8N
Systematic Name
- 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-
Registry Numbers
CAS Registry Number
- 7416-34-4
FDA UNII
- RT3Y3QMF8N
Other Registry Number
- 65973-37-7
Related Registry Number
- 15622-65-8 (mono-hydrochloride)
System Generated Number
- 0007416344
Structure Descriptors
InChI
1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3InChIKey
KLPWJLBORRMFGK-UHFFFAOYSA-NSmiles
C1OCCN(C1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 714ug/kg/D (0.714mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ANTIPSYCHOTIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 402, 1969. |
| man | TDLo | oral | 4285ug/kg/3D- (4.285mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BEHAVIORAL: MUSCLE WEAKNESS | Journal of Clinical Psychiatry. Vol. 47, Pg. 607, 1986. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 180.5 | deg C | EXP | |
| log P (octanol-water) | 2.310 | (none) | EST | |
| Atmospheric OH Rate Constant | 3.84E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.