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Substance Name: Doxazosin [INN:BAN]
RN: 74191-85-8
UNII: NW1291F1W8
InChIKey: RUZYUOTYCVRMRZ-UHFFFAOYSA-N

Note

  • A prazosin-related compound that is a selective alpha-1-adrenergic blocker.

Molecular Formula

  • C23-H25-N5-O5

Molecular Weight

  • 451.4805
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-1 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Doxazosin
  • Doxazosin [INN:BAN]

MeSH Heading

  • Doxazosin

Synonyms

  • 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin
  • 1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin
  • Doxazosin
  • Doxazosina
  • Doxazosina [Spanish]
  • Doxazosine
  • Doxazosine [French]
  • Doxazosinum
  • Doxazosinum [Latin]
  • EC 616-059-6
  • UK 33274
  • UNII-NW1291F1W8

Systematic Names

  • (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydro-1,4-benzodioxin-2-yl)methanone
  • Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-

Registry Numbers

CAS Registry Number

  • 74191-85-8

FDA UNII

  • NW1291F1W8

Other Registry Number

  • 137888-77-8

Related Registry Number

  • 77883-43-3 (mesylate)

System Generated Number

  • 0074191858

Structure Descriptors

InChI

1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)

InChIKey

RUZYUOTYCVRMRZ-UHFFFAOYSA-N

Smiles

COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.090 (none)   EST
Atmospheric OH Rate Constant 2.99E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.