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Substance Name: Cyclopenthiazide [USAN:INN:BAN:JAN]
RN: 742-20-1
UNII: VX4S2N85F5
InChIKey: BKYKPTRYDKTTJY-UHFFFAOYSA-N

Note

  • Thiazide diuretic also used as an antihypertensive agent.

Molecular Formula

  • C13-H18-Cl-N3-O4-S2

Molecular Weight

  • 379.8872
 

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Diuretics
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Natriuretic Agents
  • Sodium Chloride Symporter Inhibitors
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Names and Synonyms

Name of Substance

  • Cyclopenthiazide
  • Cyclopenthiazide [USAN:INN:BAN:JAN]

MeSH Heading

  • Cyclopenthiazide

Synonyms

  • 3-Cyclopentylmethyl hydrochlorothiazide deriv
  • 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 8341-Su
  • Benesal
  • BRN 0630346
  • Ciba 8341-Su
  • Ciclopentiazida
  • Ciclopentiazida [INN-Spanish]
  • Ciclopentiazide
  • Ciclopentiazide [DCIT]
  • Cyclomethiazide
  • Cyclometiazid
  • Cyclopenthiazide
  • Cyclopenthiazidum
  • Cyclopenthiazidum [INN-Latin]
  • Cyclopentiazid
  • EINECS 212-012-5
  • Navidreks
  • Navidrex
  • Navidrex K
  • NSC 107679
  • Salimed
  • Salimid
  • Salurilo-C
  • Su 8341
  • Su-8341
  • Tsiklometiazid
  • Ultra-Minzil
  • UNII-VX4S2N85F5

Systematic Names

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
  • Cyclopenthiazide

Registry Numbers

CAS Registry Number

  • 742-20-1

FDA UNII

  • VX4S2N85F5

Other Registry Number

  • 96782-85-3

System Generated Number

  • 0000742201

Structure Descriptors

InChI

1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

InChIKey

BKYKPTRYDKTTJY-UHFFFAOYSA-N

Smiles

NS(=O)(=O)c1cc2c(NC(CC3CCCC3)NS2(=O)=O)cc1Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 232mg/kg (232mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 325, 1961.
mouse LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 314, 1982.
rat LD50 intravenous 142mg/kg (142mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 325, 1961.
rat LD50 oral 1gm/kg (1000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 238 deg C   EXP
log P (octanol-water) 1.27 (none)   EXP
Water Solubility 29.8 mg/L 25 EST
Vapor Pressure 8.74E-12 mm Hg 25 EST
Henry's Law Constant 1.06E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.15E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.