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Substance Name: Schizandrin
RN: 7432-28-2
UNII: G01BQC0879
InChIKey: YEFOAORQXAOVJQ-RZFZLAGVSA-N

Note

  • A dibenzocyclooctadiene lignan; schizandra is the plant name.

Classification Code

  • Natural Product

Molecular Formula

  • C24-H32-O7

Molecular Weight

  • 432.5098
 
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Names and Synonyms

Name of Substance

  • Schizandrin

Synonyms

  • Gomisins
  • Gomisins (Japanese)
  • Magnolia Vine
  • Omija
  • Schisandra chinensis fruit
  • Schisandrin
  • Schisandrins (Russian)
  • Schisandrol A
  • Schizandrin
  • Schizandrol A
  • UNII-G01BQC0879
  • Wu-wei-zi
  • Wuweizi alcohol A
  • Wuweizichun A
  • Wuweizins
  • Wuweizins (Chinese)

Systematic Names

  • Dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer
  • Dibenzo(a,c)cycloocten-6-ol, 5,6,7,8-tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxy-, stereoisomer

Registry Numbers

CAS Registry Number

  • 7432-28-2

FDA UNII

  • G01BQC0879

System Generated Number

  • 0007432282

Structure Descriptors

InChI

1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3/t13-,24-/m0/s1

InChIKey

YEFOAORQXAOVJQ-RZFZLAGVSA-N

Smiles

COc1cc2C[C@H](C)[C@@](C)(O)Cc3cc(OC)c(OC)c(OC)c3c2c(OC)c1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 518mg/kg (518mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
mouse LD50 oral 1448mg/kg (1448mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
mouse LD50 oral 1448mg/kg (1448mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
mouse LD50 subcutaneous 1861mg/kg (1861mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.