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Substance Name: Amoxicillin mixture with Clavulanate potassium
RN: 74469-00-4
InChIKey: DWHGNUUWCJZQHO-ZVDZYBSKSA-M

Note

  • A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.

Molecular Formula

  • C16-H19-N3-O5-S.C8-H9-N-O5.K

Molecular Weight

  • 602.6593
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • beta-Lactamase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Reproductive Effect

Names and Synonyms

Results Name

  • Amoxicillin mixture with Clavulanate potassium

Name of Substance

  • Amoxicillin-potassium clavulanate combination

MeSH Heading

  • Amoxicillin-potassium clavulanate combination

Synonyms

  • Amocla
  • Amoclan
  • Amoclav
  • Amoxicillin / clavulanic acid
  • Amoxicillin and clavulanate potassium
  • Amoxicillin clavulanate potassium
  • Amoxicillin mixed with potassium clavulanate (2:1)
  • Amoxicillin mixture with Clavulanate potassium
  • Amoxsiklav
  • Ancla
  • Augmentan
  • Augmentin
  • Augmentin '125'
  • Augmentin '200'
  • Augmentin '250'
  • Augmentin '400'
  • Augmentin '500'
  • Augmentin '875'
  • Augmentin (antibiotic)
  • Augmentin ES-600
  • Augmentin XR
  • Augmentine
  • Auspilic
  • BRL 25000
  • BRL 25000A
  • BRL 25000G
  • Clamentin
  • Clamobit
  • Clavam
  • Clavam 625
  • Clavamox
  • Clavinex
  • Clavoxilin Plus
  • Clavulin
  • Clavumox
  • Co-Amoxiclav
  • Curam
  • Eumetinex
  • Kmoxilin
  • Potassium clavulanate mixed with amoxicillin (1:2)
  • Spectramox
  • Viaclav
  • Xiclav

Systematic Names

  • 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)-, mixt. with (2S,5R,6R)-6-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
  • 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R-(2-alpha,3Z,5-alpha))-, mixt. with (2S-(2-alpha,5-alpha,6-beta(S*)))-6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid (1:2)

Registry Numbers

CAS Registry Number

  • 74469-00-4

Other Registry Number

  • 74428-36-7

Related Registry Number

  • 79198-29-1 (parent)

System Generated Number

  • 0074469004

Molecular Formulas

Molecular Formula

  • C16-H19-N3-O5-S.C8-H9-N-O5.K

Molecular Formula Fragments

  • C16-H19-N3-O5-S
  • C8-H9-N-O5
  • COMPONENT
  • K

Structure Descriptors

InChI

InChI=1S/C16H19N3O5S.C8H9NO5.K/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);1,6-7,10H,2-3H2,(H,12,13);/q;;+1/p-1/b;4-1-;/t9-,10-,11+,14-;6-,7-;/m11./s1

InChIKey

DWHGNUUWCJZQHO-ZVDZYBSKSA-M

Smiles

[K+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O.OC\C=C\4/O[C@@H]5CC(=O)N5[C@H]4C(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 600mg/kg/28D- (600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

BLOOD: EOSINOPHILIA

LIVER: "JAUNDICE, CHOLESTATIC"		 Acta Clinica Belgica. Vol. 46, Pg. 327, 1991.
mouse LD50 intraperitoneal 3925mg/kg (3925mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Chemotherapy Vol. 31(Suppl,
mouse LD50 oral > 15gm/kg (15000mg/kg)   Chemotherapy Vol. 31(Suppl,
mouse LD50 subcutaneous 6433mg/kg (6433mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Chemotherapy Vol. 31(Suppl,
rat LD50 intraperitoneal 2774mg/kg (2774mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Chemotherapy Vol. 31(Suppl,
rat LD50 oral > 15gm/kg (15000mg/kg)   Chemotherapy Vol. 31(Suppl,
rat LD50 subcutaneous 3487mg/kg (3487mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Chemotherapy Vol. 31(Suppl,