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Substance Name: Fonazine
RN: 7456-24-8
UNII: 1FTA475ZDB
InChIKey: VWNWVCJGUMZDIU-UHFFFAOYSA-N

Note

  • Has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions.

Molecular Formula

  • C19-H25-N3-O2-S2

Molecular Weight

  • 391.5575
 

Classification Codes

  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Fonazine

Name of Substance

  • Dimetotiazine [INN:BAN]
  • Fonazine

Synonyms

  • 10-(2-(Dimethylamino)propyl)-N,N-dimethylphenothiazine-2-sulfonamide
  • 3-Dimethylsulfonamido 10-(2-dimethylaminopropyl)phenothiazine
  • Banistyl
  • Bayer 1483
  • BRN 0941549
  • Dimethodin
  • Dimethothiazine
  • Dimethylsulfamido-3-(dimethylamino-2-propyl)-10-phenothiazine
  • Dimetiotazine
  • Dimetotiazina
  • Dimetotiazina [INN-Spanish]
  • Dimetotiazine
  • Dimetotiazinum
  • Dimetotiazinum [INN-Latin]
  • EINECS 231-229-6
  • Fonazine
  • IL 6302
  • N,N-Dimethyl-10-(2-dimethylaminopropyl)-2-phenothiazinylsulfonamid
  • R.P. 8599
  • UNII-1FTA475ZDB

Systematic Names

  • Dimetotiazine
  • Phenothiazine-2-sulfonamide, 10-(2-(dimethylamino)propyl)-N,N-dimethyl-

Registry Numbers

CAS Registry Number

  • 7456-24-8

FDA UNII

  • 1FTA475ZDB

Related Registry Number

  • 13115-40-7 (monomesylate)

System Generated Number

  • 0007456248

Structure Descriptors

InChI

1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3

InChIKey

VWNWVCJGUMZDIU-UHFFFAOYSA-N

Smiles

CC(CN1c2ccccc2Sc3c1cc(cc3)S(=O)(=O)N(C)C)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 190mg/kg (190mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 159, Pg. 70, 1966.
mouse LD50 intravenous 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 159, Pg. 70, 1966.
mouse LD50 oral 740mg/kg (740mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 159, Pg. 70, 1966.
mouse LD50 subcutaneous 475mg/kg (475mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 159, Pg. 70, 1966.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.540 (none)   EST
Atmospheric OH Rate Constant 2.13E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.