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Substance Name: Tegafur mixture with with Uracil
RN: 74578-38-4
UNII: HMI5GR78FR
InChIKey: DHMYGZIEILLVNR-UHFFFAOYSA-N

Note

  • A drug containing tegafur and uracil; a biochemical modulator of 5-fluorouracil; used for postoperative chemotherapy of colon cancer; reported to cause severe liver injury; do not confuse with 1-UFT protocol.

Molecular Formula

  • C8-H9-F-N2-O3.C4-H4-N2-O2

Molecular Weight

  • 312.2557
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Tegafur mixture with with Uracil

Name of Substance

  • UFT(R) drug

Synonyms

  • 1-(2-Tetrahydrofuryl)-5-fluorouracil mixt. with uracil (1:4)
  • FT mixt. with uracil (1:4)
  • Tegafur - uracil mixture
  • Tegafur / uracil
  • Tegafur mixt. with uracil (1:4)
  • UFT
  • Uftoral
  • Ufur
  • UNII-HMI5GR78FR
  • Uracil mixt. with 1-(2-tetrahydrofuryl)-5-fluorouracil (4:1)
  • Uracil mixt. with FT (4:1)
  • Uracil mixt. with tegafur (4:1)
  • Uracil-Tegafur
  • Youfuding

Systematic Names

  • 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, mixt. with 2,4(1H,3H)-pyrimidinedione
  • Uracil, 5-fluoro-1-(tetrahydro-2-furyl)- mixt. with uracil (1:4)

Registry Numbers

CAS Registry Number

  • 74578-38-4

FDA UNII

  • HMI5GR78FR

System Generated Number

  • 0074578384

Molecular Formulas

Molecular Formula

  • C8-H9-F-N2-O3.C4-H4-N2-O2

Molecular Formula Fragments

  • C4-H4-N2-O2
  • C8-H9-F-N2-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C8H9FN2O3.C4H4N2O2/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12;7-3-1-2-5-4(8)6-3/h4,6H,1-3H2,(H,10,12,13);1-2H,(H2,5,6,7,8)

InChIKey

DHMYGZIEILLVNR-UHFFFAOYSA-N

Smiles

FC1=CN(C2CCCO2)C(=O)NC1=O.O=C3NC=CC(=O)N3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 150mg/kg (150mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

VASCULAR: OTHER CHANGES

BEHAVIORAL: TREMOR
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1009, 1980.
mouse LD50 oral 1275mg/kg (1275mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1009, 1980.
rabbit LD50 oral 242mg/kg (242mg/kg) VASCULAR: OTHER CHANGES Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1009, 1980.
rat LD50 oral 1580mg/kg (1580mg/kg) BLOOD: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1009, 1980.