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Substance Name: Ceftriaxone Sodium [USP]
RN: 74578-69-1
UNII: R598PB148Q
InChIKey: LTFQVRWXHBGEMZ-BBJOQENWSA-L

Note

  • A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

Molecular Formula

  • C18-H18-N8-O7-S3.2Na

Molecular Weight

  • 598.5514
 

Classification Codes

  • Antibiotics
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Name of Substance

  • Ceftriaxone Sodium [USP]

Synonyms

  • Ceftriaxone and dextrose in duplex container
  • Ceftriaxone disodium
  • Ceftriaxone in plastic container
  • Ceftriaxone sodium
  • EINECS 277-930-0
  • Lendacin
  • Longaceph
  • Ro 13-9904
  • Ro 13-9904/001
  • Rocephin
  • Rocephin w/ dextrose in plastic container
  • Tartriakson
  • UNII-R598PB148Q
  • X 13-9904

Systematic Name

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, disodium salt, (6R-(6alpha,7beta(Z)))-

Registry Numbers

CAS Registry Number

  • 74578-69-1

FDA UNII

  • R598PB148Q

Related Registry Number

  • 73384-59-5 (Parent)

System Generated Number

  • 0074578691

Molecular Formulas

Molecular Formula

  • C18-H18-N8-O7-S3.2Na

Molecular Formula Fragments

  • C18-H18-N8-O7-S3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C18H18N8O7S3.2Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;/h5,9,15H,3-4H2,1-2H3,(H5,19,20,21,23,27,29,31,32);;/q;2*+1/p-2/b24-8-;;/t9-,15-;;/m1../s1

InChIKey

LTFQVRWXHBGEMZ-BBJOQENWSA-L

Smiles

Cn1c(nc(=O)c(=O)[n-]1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/c4csc(n4)N)SC2)C(=O)[O-].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. -, Pg. 676, 1995.
infant TDLo intramuscular 16mg/kg/3D-I (16mg/kg)   Clinical Pediatrics Vol. 32, Pg. 360, 1993.
infant TDLo intramuscular 16mg/kg/3D-I (16mg/kg) BRAIN AND COVERINGS: MENINGEAL CHANGES

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Clinical Pediatrics Vol. 32, Pg. 360, 1993.
man TDLo multiple routes 800mg/kg/49D- (800mg/kg) BLOOD: AGRANULOCYTOSIS

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Israel Journal of Medical Sciences. Vol. 29, Pg. 52, 1993.
mouse LD50 intravenous 2200mg/kg (2200mg/kg)   Journal of Antibiotics. Vol. 33, Pg. 783, 1980.
mouse LD50 oral > 10gm/kg (10000mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
rat LD50 intravenous 1900mg/kg (1900mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
rat LD50 oral > 10gm/kg (10000mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   "Ceftriaxon Vol. -, Pg. 91, 1982.
women TDLo multiple routes 640mg/kg/32D- (640mg/kg)   Israel Journal of Medical Sciences. Vol. 29, Pg. 52, 1993.
women TDLo multiple routes 640mg/kg/32D- (640mg/kg) BLOOD: AGRANULOCYTOSIS

GASTROINTESTINAL: NAUSEA OR VOMITING
Israel Journal of Medical Sciences. Vol. 29, Pg. 52, 1993.