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Substance Name: Docarpamine [INN]
RN: 74639-40-0
UNII: RPQ57D8S72
InChIKey: ZLVMAMIPILWYHQ-INIZCTEOSA-N

Note

  • A dopamine prodrug.

Molecular Formula

  • C21-H30-N2-O8-S

Molecular Weight

  • 470.54
 

Classification Codes

  • Dopamine Agents
  • Dopamine Agonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Docarpamine
  • Docarpamine [INN]

Synonyms

  • Docarpamina
  • Docarpamina [INN-Spanish]
  • Docarpamine
  • Docarpaminum
  • Docarpaminum [INN-Latin]
  • N-(N-Acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine
  • TA-870
  • UNII-RPQ57D8S72

Systematic Names

  • (-)-(S)-2-Acetamido-N-(3,4-dihydroxyphenethyl)-4-(methylthio)butyramide bis(ethyl carbonate) (ester)
  • Carbonic acid, 4-(2-((2-(acetylamino)-4-(methylthio)-1-oxobutyl)amino)ethyl)-1,2-phenylene diethyl ester, (S)-

Registry Numbers

CAS Registry Number

  • 74639-40-0

FDA UNII

  • RPQ57D8S72

System Generated Number

  • 0074639400

Structure Descriptors

InChI

InChI=1S/C21H30N2O8S/c1-5-28-20(26)30-17-8-7-15(13-18(17)31-21(27)29-6-2)9-11-22-19(25)16(10-12-32-4)23-14(3)24/h7-8,13,16H,5-6,9-12H2,1-4H3,(H,22,25)(H,23,24)/t16-/m0/s1

InChIKey

ZLVMAMIPILWYHQ-INIZCTEOSA-N

Smiles

CCOC(=O)Oc1ccc(CCNC(=O)[C@H](CCSC)NC(=O)C)cc1OC(=O)OCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 2gm/kg (2000mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 101, 1992.
dog LD50 subcutaneous > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 836, 1995.
rat LD50 oral 2gm/kg (2000mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 101, 1992.
rat LD50 subcutaneous 1gm/kg (1000mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 101, 1992.