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Substance Name: Hydroxychloroquine sulfate [USP]
RN: 747-36-4
UNII: 8Q2869CNVH
InChIKey: JCBIVZZPXRZKTI-UHFFFAOYSA-N

Note

  • A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)

Molecular Formula

  • C18-H26-Cl-N3-O.H2-O4-S

Molecular Weight

  • 433.9542
 

Classification Codes

  • Antimalarial
  • Human Data
  • Suppressant (Lupus Erythematosus)
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Names and Synonyms

Name of Substance

  • Hydroxychloroquine sulfate [USP]

Synonyms

  • (+-)-2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt)
  • 2-((4-((7-Chloro-4-quinolinyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt)
  • 2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate (1:1) (salt)
  • AI3-52706
  • EINECS 212-019-3
  • Ercoquin
  • Ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethyl)amino-, (+-)-, sulfate (1:1) salt
  • Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-, sulfate (1:1) (salt)
  • Hydroxychloroquine sulfate
  • NSC 4375
  • Plaquenil
  • Plaquinol
  • Toremonil
  • UNII-8Q2869CNVH

Systematic Names

  • Ethanol, 2-((4-((7-chloro-4-quinolinyl)amino)pentyl)ethylamino)-, sulfate (1:1)
  • Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)-, sulfate (1:1) (salt) (8CI)
  • Hydroxychloroquine sulphate

Registry Numbers

CAS Registry Number

  • 747-36-4

FDA UNII

  • 8Q2869CNVH

Related Registry Number

  • 118-42-3 (Parent)

System Generated Number

  • 0000747364

Molecular Formulas

Molecular Formula

  • C18-H26-Cl-N3-O.H2-O4-S

Molecular Formula Fragments

  • C18-H26-Cl-N3-O
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChIKey

JCBIVZZPXRZKTI-UHFFFAOYSA-N

Smiles

CCN(CCCC(C)Nc1ccnc2c1ccc(c2)Cl)CCO.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 600mg/kg (600mg/kg) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of Analytical Toxicology. Vol. 14, Pg. 186, 1990.
women TDLo oral 400mg/kg (400mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 861, 1999.