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Substance Name: Spiroplatin [USAN:INN:BAN]
RN: 74790-08-2
UNII: H2V318W7LE
InChIKey: XASGSSXPZXRXFL-UHFFFAOYSA-L

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C8-H18-N2-O4-Pt-S

Molecular Weight

  • 433.386
 
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Names and Synonyms

Name of Substance

  • Spiroplatin
  • Spiroplatin [USAN:INN:BAN]

Synonyms

  • CCRIS 3649
  • cis-(1,1-Cyclohexanebis(methylamine))(sulfato)platinum
  • EINECS 277-997-6
  • Espiroplatino
  • Espiroplatino [Spanish]
  • NSC 311056
  • Platinum, (1,1-cyclohexanedimethanamine-N,N')(sulfato(2-)-O,O')-, (SP-4-2)-
  • Spiroplatin
  • Spiroplatine
  • Spiroplatine [French]
  • Spiroplatinum
  • Spiroplatinum [Latin]
  • TNO 6
  • TNO-6
  • UNII-H2V318W7LE

Systematic Names

  • (Cyclohexane-1,1-diylbis(methylamine)-N,N')(sulphato(2-)-O,O')platinum
  • 1,1-Cyclohexanedimethanamine, platinum complex (9CI)
  • Platinum, (1,1-cyclohexanedimethanamine-N,N')(sulfato(2-)-O,O')-, (SP-4-2)-
  • Spiroplatin

Registry Numbers

CAS Registry Number

  • 74790-08-2

FDA UNII

  • H2V318W7LE

System Generated Number

  • 0074790082

Structure Descriptors

InChI

1S/C8H18N2.H2O4S.Pt/c9-6-8(7-10)4-2-1-3-5-8;1-5(2,3)4;/h1-7,9-10H2;(H2,1,2,3,4);/q;;+2/p-2

InChIKey

XASGSSXPZXRXFL-UHFFFAOYSA-L

Smiles

O=S1(=O)O[Pt]2(NCC3(CN2)CCCCC3)O1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 13mg/kg (13mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 20, Pg. 1087, 1984.
mouse LD50 intravenous 8900ug/kg (8.9mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 20, Pg. 1087, 1984.
rat LD50 intravenous 4mg/kg (4mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 20, Pg. 1087, 1984.