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Substance Name: Magnesium sulfate anhydrous
RN: 7487-88-9
UNII: ML30MJ2U7I
InChIKey: CSNNHWWHGAXBCP-UHFFFAOYSA-L

Note

  • A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Molecular Formulas

  • H2-O4-S.Mg
  • O4-S.Mg

Molecular Weight

  • 120.367
 

Classification Codes

  • Analgesics
  • Anesthetics
  • Anti-Arrhythmia Agents
  • Anticonvulsants
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Membrane Transport Modulators
  • Mutation Data
  • Peripheral Nervous System Agents
  • Reproductive Control Agents
  • Reproductive Effect
  • Sensory System Agents
  • Tocolytic Agents

Names and Synonyms

Name of Substance

  • Magnesium sulfate
  • Magnesium sulfate anhydrous
  • Sulfuric acid, magnesium salt (1:1)

MeSH Heading

  • Magnesium sulfate

Synonyms

  • Arrosalt 2327
  • Caswell No. 534
  • CCRIS 8411
  • EC 231-298-2
  • EINECS 231-298-2
  • EPA Pesticide Chemical Code 050503
  • Epsom salt
  • Epsom salts
  • HSDB 664
  • Magnesii sulfas
  • Magnesium sulfate
  • Magnesium sulfate (1:1)
  • Magnesium sulfate in dextrose 5% in plastic container
  • Magnesium sulfate in plastic container
  • Magnesium sulphate
  • NSC 146179
  • OT-S
  • OT-S (drying agent)
  • Sal Angalis
  • Sal De sedlitz
  • SN 00
  • Sulfato de magnesio
  • Sulfuric acid magnesium salt
  • Sulfuric acid magnesium salt (1:1)
  • Sulfuric acid magnesium salt (VAN)
  • Tomix OT
  • UNII-ML30MJ2U7I

Systematic Names

  • Magnesium sulfate (1:1)
  • Magnesium sulphate
  • Sulfuric acid magnesium salt (1:1)

Superlist Name

  • Magnesium sulfate

Registry Numbers

CAS Registry Number

  • 7487-88-9

FDA UNII

  • ML30MJ2U7I

Other Registry Numbers

  • 139939-75-6
  • 849607-35-8

Related Registry Number

  • 10034-99-8 (heptahydrate)

System Generated Number

  • 0007487889

Molecular Formulas

Molecular Formulas

  • H2-O4-S.Mg
  • O4-S.Mg

Molecular Formula Fragments

  • COMPONENT
  • H2-O4-S
  • Mg
  • O4-S

Structure Descriptors

InChI

1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2

InChIKey

CSNNHWWHGAXBCP-UHFFFAOYSA-L

Smiles

S(=O)(=O)([O-])[O-].[Mg+2]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 1gm/kg (1000mg/kg) BEHAVIORAL: GENERAL ANESTHETIC American Journal of Physiology. Vol. 14, Pg. 366, 1905.
dog LDLo intraperitoneal 1200mg/kg (1200mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935.
dog LDLo subcutaneous 1500mg/kg (1500mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935.
guinea pig LDLo subcutaneous 1800mg/kg (1800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: GENERAL ANESTHETIC
American Journal of Physiology. Vol. 14, Pg. 366, 1905.
man TDLo oral 428mg/kg (428mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Japanese Journal of Toxicology. Vol. 2, Pg. 285, 1989.
mouse LD50 intraperitoneal 1029mg/kg (1029mg/kg)   Farmakologiya i Toksikologiya Vol. 10, Pg. 107, 1975.
mouse LD50 subcutaneous 645mg/kg (645mg/kg)   Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 7, Pg. 178, 1986.
mouse LDLo intravenous 48mg/kg (48mg/kg)   Toxicology and Applied Pharmacology. Vol. 4, Pg. 492, 1962.
mouse LDLo oral 5gm/kg (5000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935.
rabbit LDLo oral 3gm/kg (3000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935.
rabbit LDLo subcutaneous 1750mg/kg (1750mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
American Journal of Physiology. Vol. 14, Pg. 366, 1905.
rat LD50 subcutaneous 1200mg/kg (1200mg/kg)   Neuroscience Letters. Vol. 117, Pg. 207, 1990.
women LDLo intravenous 80mg/kg/2M-I (80mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
South African Medical Journal. Vol. 67, Pg. 145, 1985.
women TDLo intraspinal 20mg/kg (20mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITH APPROPRIATE ANESTHESIA South African Medical Journal. Vol. 68, Pg. 367, 1985.
women TDLo oral 351mg/kg (351mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

BEHAVIORAL: MUSCLE WEAKNESS

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Journal of Toxicology, Clinical Toxicology. Vol. 34, Pg. 735, 1996.