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Substance Name: Ethyl chloride [USP]
RN: 75-00-3
UNII: 46U771ERWK
InChIKey: HRYZWHHZPQKTII-UHFFFAOYSA-N

Note

  • A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine.

Molecular Formula

  • C2-H5-Cl

Molecular Weight

  • 64.5145
 

Classification Codes

Classification Codes

  • Anesthetic (Topical)
  • Anesthetics
  • Anesthetics, Local
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Mutation Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 183
  • 2011 CERCLA Priority List, Rank: 178
  • Overall Carcinogenic Evaluation: Group 3
  • Reportable Quantity (RQ) = 100 lb
  • TWA (100 ppm); skin; Confirmed animal carcinogen with unknown relevance to humans
  • TWA 1000 ppm (2600 mg/m3)

Names and Synonyms

Name of Substance

  • Ethyl chloride
  • Ethyl chloride [USP]

MeSH Heading

  • Ethyl chloride

Synonyms

  • Aethylchlorid
  • Aethylchlorid [German]
  • Aethylchloride
  • Aethylchloride [German]
  • Aethylis chloridum
  • AI3-24474
  • Anodynon
  • CCRIS 3349
  • Chelen
  • Chloorethaan
  • Chloorethaan [Dutch]
  • Chlorene
  • Chlorethyl
  • Chloroaethan
  • Chloroaethan [German]
  • Chloroethane
  • Chlorure d'ethyle
  • Chlorure d'ethyle [French]
  • Chloryl
  • Chloryl anesthetic
  • Cloretilo
  • Cloroetano
  • Cloroetano [Italian]
  • Cloruro di etile
  • Cloruro di etile [Italian]
  • Dublofix
  • EC 200-830-5
  • EINECS 200-830-5
  • Ethane, chloro-
  • Ether chloratus
  • Ether chloridum
  • Ether hydrochloric
  • Ether muriatic
  • Ethyl chloride
  • Etylu chlorek
  • Etylu chlorek [Polish]
  • HSDB 533
  • Hydrochloric ether
  • Kelene
  • Monochlorethane
  • Monochloroethane
  • Muriatic ether
  • Narcotile
  • NCI-C06224
  • UNII-46U771ERWK

Systematic Names

  • Chloroethane
  • Ethane, chloro-

Superlist Names

  • Chloroethane
  • Ethane, chloro-
  • Ethyl chloride
  • Ethyl chloride [UN1037] [Flammable gas]
  • Monochloroethane
  • UN1037

Registry Numbers

CAS Registry Number

  • 75-00-3

FDA UNII

  • 46U771ERWK

System Generated Number

  • 0000075003

Structure Descriptors

InChI

1S/C2H5Cl/c1-2-3/h2H2,1H3

InChIKey

HRYZWHHZPQKTII-UHFFFAOYSA-N

Smiles

C(C)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LCLo inhalation 40000ppm/45M (40000ppm) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
U.S. Public Health Service, Public Health Bulletin. Vol. 185, Pg. 1, 1929.
mouse LC50 inhalation 146gm/m3/2H (146000mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 66, 1982.
rat LC50 inhalation 152gm/m3/2H (152000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

BLOOD: HEMORRHAGE
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 6, Pg. 45, 1964.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.39E+02 deg C   EXP
Boiling Point 12.3 deg C   EXP
log P (octanol-water) 1.43 (none)   EXP
Water Solubility 6710 mg/L 25 EXP
Vapor Pressure 1010 mm Hg 20 EXP
Henry's Law Constant 0.0111 atm-m3/mole 24 EXP
Atmospheric OH Rate Constant 4.11E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.