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Substance Name: Methylene chloride [NF]
RN: 75-09-2
UNII: 588X2YUY0A
InChIKey: YMWUJEATGCHHMB-UHFFFAOYSA-N

Note

  • A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.

Molecular Formula

  • C-H2-Cl2

Molecular Weight

  • 84.9328
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Drug / Therapeutic Agent
  • Growth Regulator / Fertilizer
  • Human Data
  • Mutation Data
  • Pharmaceutic Aid (Solvent)
  • Reproductive Effect
  • Skin / Eye Irritant
  • TSCA Flag R (Subject to a Section 6 Risk Management Rule under TSCA)
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 80
  • 2011 CERCLA Priority List, Rank: 86
  • Overall Carcinogenic Evaluation: Group 2B
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 1000 lb
  • TWA (50 ppm); Confirmed animal carcinogen with unknown relevance to humans; BEI
  • TWA see 1919.52

Names and Synonyms

Name of Substance

  • Dichloromethane
  • Methylene chloride
  • Methylene chloride [NF]

MeSH Heading

  • Methylene chloride

Synonyms

  • 4-01-00-00035 (Beilstein Handbook Reference)
  • Aerothene MM
  • AI3-01773
  • BRN 1730800
  • Caswell No. 568
  • CCRIS 392
  • Chlorure de methylene
  • Chlorure de methylene [French]
  • Dichloromethane
  • EC 200-838-9
  • EINECS 200-838-9
  • EPA Pesticide Chemical Code 042004
  • F 30
  • F 30 (chlorocarbon)
  • Freon 30
  • HCC 30
  • HSDB 66
  • Khladon 30
  • Metaclen
  • Methane dichloride
  • Methane, dichloro-
  • Methylene bichloride
  • Methylene chloride
  • Methylene dichloride
  • Methylenum chloratum
  • Metylenu chlorek
  • Metylenu chlorek [Polish]
  • Narkotil
  • NCI-C50102
  • NSC 406122
  • R 30
  • R30 (refrigerant)
  • RCRA waste number U080
  • Solaesthin
  • Soleana VDA
  • Solmethine
  • UN 1593
  • UNII-588X2YUY0A

Systematic Names

  • Dichloromethane
  • Methane, dichloro-
  • Methylene chloride

Superlist Names

  • Dichloromethane
  • Dichloromethane [UN1593] [Poison]
  • Methane, dichloro-
  • Methylene chloride
  • RCRA waste no. U080
  • UN1593

Registry Numbers

CAS Registry Number

  • 75-09-2

FDA UNII

  • 588X2YUY0A

System Generated Number

  • 0000075092

Structure Descriptors

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChIKey

YMWUJEATGCHHMB-UHFFFAOYSA-N

Smiles

C(Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 43400mg/m3/4. (43400mg/m3)   Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
cat LCLo inhalation 43400mg/m3/4. (43400mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: ATAXIA
Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936.
dog LCLo inhalation 14108ppm/7H (14108ppm) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949.
dog LD50 intraperitoneal 1274mg/kg (1274mg/kg)   Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.
dog LDLo intravenous 200mg/kg (200mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
dog LDLo oral 3gm/kg (3000mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
guinea pig LCLo inhalation 5000ppm/2H (5000ppm)   Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967.
human LDLo oral 357mg/kg (357mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

PERIPHERAL NERVE AND SENSATION: PARESTHESIS
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 390, 1969.
human TCLo inhalation 500ppm/1Y-I (500ppm) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

CARDIAC: CHANGE IN RATE
Abstracts on Hygiene. Vol. 43, Pg. 1123, 1968.
human TCLo inhalation 500ppm/8H (500ppm) BEHAVIORAL: EUPHORIA Science. Vol. 176, Pg. 295, 1972.
man TDLo oral 1429uL/kg (1.429mL/kg) BLOOD: NORMOCYTIC ANEMIA

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 575, 1994.
mouse LC50 inhalation 14400ppm/7H (14400ppm)   National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949.
mouse LD50 intraperitoneal 437mg/kg (437mg/kg)   Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960.
mouse LD50 oral 873mg/kg (873mg/kg)   EHP, Environmental Health Perspectives. Vol. 106(Suppl,
mouse LD50 subcutaneous 6460mg/kg (6460mg/kg)   Toxicology and Applied Pharmacology. Vol. 4, Pg. 354, 1962.
mouse LD50 unreported 4770mg/kg (4770mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Eisei Kagaku. Hygienic Chemistry. Vol. 28, Pg. P31, 1982.
rabbit LCLo inhalation 10000ppm/7H (10000ppm)   Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 8, 1944.
rabbit LD50 unreported 1225mg/kg (1225mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988.
rabbit LDLo oral 1900mg/kg (1900mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 94, 1955.
rabbit LDLo subcutaneous 2700mg/kg (2700mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
rat LC50 inhalation 52gm/m3 (52000mg/m3)   Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979.
rat LD50 intraperitoneal 916mg/kg (916mg/kg)   Environmental Research. Vol. 40, Pg. 411, 1986.
rat LD50 oral 1600mg/kg (1600mg/kg) BEHAVIORAL: ATAXIA FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 94, 1970.
rat LD50 unreported 5350mg/kg (5350mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988.
rat LDLo intratracheal 350mg/kg (350mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
National Technical Information Service. Vol. OTS0520615,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -9.51E+01 deg C   EXP
Boiling Point 40 deg C   EXP
log P (octanol-water) 1.25 (none)   EXP
Water Solubility 1.30E+04 mg/L 25 EXP
Vapor Pressure 435 mm Hg 25 EXP
Henry's Law Constant 0.00325 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.42E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.