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Substance Name: Methylene chloride [NF]
RN: 75-09-2
UNII: 588X2YUY0A
InChIKey: YMWUJEATGCHHMB-UHFFFAOYSA-N
Note
- A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.
Molecular Formula
- C-H2-Cl2
Molecular Weight
- 84.9328
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Agricultural Chemical
- Drug / Therapeutic Agent
- Growth Regulator / Fertilizer
- Human Data
- Mutation Data
- Pharmaceutic Aid (Solvent)
- Reproductive Effect
- Skin / Eye Irritant
- TSCA Flag R (Subject to the TSCA Section 6 Risk Management Rule)
- Tumor Data
Superlist Classification Codes
- 2007 CERCLA Priority List, Rank: 80
- 2011 CERCLA Priority List, Rank: 86
- Overall Carcinogenic Evaluation: Group 2B
- Reasonably Anticipated to be a Carcinogen
- Reportable Quantity (RQ) = 1000 lb
- TWA (50 ppm); Confirmed animal carcinogen with unknown relevance to humans; BEI
- TWA see 1919.52
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Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Dichloromethane
- Methylene chloride
- Methylene chloride [NF]
MeSH Heading
- Methylene chloride
Synonyms
- 4-01-00-00035 (Beilstein Handbook Reference)
- Aerothene MM
- AI3-01773
- BRN 1730800
- Caswell No. 568
- CCRIS 392
- Chlorure de methylene
- Chlorure de methylene [French]
- Dichloromethane
- EC 200-838-9
- EINECS 200-838-9
- EPA Pesticide Chemical Code 042004
- F 30
- F 30 (chlorocarbon)
- Freon 30
- HCC 30
- HSDB 66
- Khladon 30
- Metaclen
- Methane dichloride
- Methane, dichloro-
- Methylene bichloride
- Methylene chloride
- Methylene dichloride
- Methylenum chloratum
- Metylenu chlorek
- Metylenu chlorek [Polish]
- Narkotil
- NCI-C50102
- NSC 406122
- R 30
- R30 (refrigerant)
- RCRA waste number U080
- Solaesthin
- Soleana VDA
- Solmethine
- UN 1593
- UNII-588X2YUY0A
Systematic Names
- Dichloromethane
- Methane, dichloro-
- Methylene chloride
Superlist Names
- Dichloromethane
- Dichloromethane [UN1593] [Poison]
- Methane, dichloro-
- Methylene chloride
- RCRA waste no. U080
- UN1593
Registry Numbers
CAS Registry Number
- 75-09-2
FDA UNII
- 588X2YUY0A
Other Registry Number
- 1173020-57-9
System Generated Number
- 0000075092
Structure Descriptors
InChI
InChI=1S/CH2Cl2/c2-1-3/h1H2InChIKey
YMWUJEATGCHHMB-UHFFFAOYSA-NSmiles
ClCClToxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LCLo | inhalation | 43400mg/m3/4. (43400mg/m3) | Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936. | |
cat | LCLo | inhalation | 43400mg/m3/4. (43400mg/m3) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA | Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936. |
dog | LCLo | inhalation | 14108ppm/7H (14108ppm) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. |
dog | LD50 | intraperitoneal | 1274mg/kg (1274mg/kg) | Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967. | |
dog | LDLo | intravenous | 200mg/kg (200mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
dog | LDLo | oral | 3gm/kg (3000mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
guinea pig | LCLo | inhalation | 5000ppm/2H (5000ppm) | Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967. | |
human | LDLo | oral | 357mg/kg (357mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: PARESTHESIS | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 390, 1969. |
human | TCLo | inhalation | 500ppm/1Y-I (500ppm) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: CHANGE IN RATE | Abstracts on Hygiene. Vol. 43, Pg. 1123, 1968. |
human | TCLo | inhalation | 500ppm/8H (500ppm) | BEHAVIORAL: EUPHORIA | Science. Vol. 176, Pg. 295, 1972. |
man | TDLo | oral | 1429uL/kg (1.429mL/kg) | BLOOD: NORMOCYTIC ANEMIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 575, 1994. |
mouse | LC50 | inhalation | 14400ppm/7H (14400ppm) | National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. | |
mouse | LD50 | intraperitoneal | 437mg/kg (437mg/kg) | Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960. | |
mouse | LD50 | oral | 873mg/kg (873mg/kg) | EHP, Environmental Health Perspectives. Vol. 106(Suppl, | |
mouse | LD50 | subcutaneous | 6460mg/kg (6460mg/kg) | Toxicology and Applied Pharmacology. Vol. 4, Pg. 354, 1962. | |
mouse | LD50 | unreported | 4770mg/kg (4770mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | Eisei Kagaku. Hygienic Chemistry. Vol. 28, Pg. P31, 1982. |
rabbit | LCLo | inhalation | 10000ppm/7H (10000ppm) | Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 8, 1944. | |
rabbit | LD50 | unreported | 1225mg/kg (1225mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988. | |
rabbit | LDLo | oral | 1900mg/kg (1900mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 94, 1955. | |
rabbit | LDLo | subcutaneous | 2700mg/kg (2700mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
rat | LC50 | inhalation | 52gm/m3 (52000mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979. | |
rat | LD50 | intraperitoneal | 916mg/kg (916mg/kg) | Environmental Research. Vol. 40, Pg. 411, 1986. | |
rat | LD50 | oral | 1600mg/kg (1600mg/kg) | BEHAVIORAL: ATAXIA | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 94, 1970. |
rat | LD50 | unreported | 5350mg/kg (5350mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988. | |
rat | LDLo | intratracheal | 350mg/kg (350mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | National Technical Information Service. Vol. OTS0520615, |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -9.51E+01 | deg C | EXP | |
Boiling Point | 40 | deg C | EXP | |
log P (octanol-water) | 1.25 | (none) | EXP | |
Water Solubility | 1.30E+04 | mg/L | 25 | EXP |
Vapor Pressure | 435 | mm Hg | 25 | EXP |
Henry's Law Constant | 0.00325 | atm-m3/mole | 25 | EXP |
Atmospheric OH Rate Constant | 1.42E-13 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.