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Substance Name: Ethylene oxide
RN: 75-21-8
UNII: JJH7GNN18P
InChIKey: IAYPIBMASNFSPL-UHFFFAOYSA-N
Note
- A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794).
Molecular Formula
- C2-H4-O
Molecular Weight
- 44.0526
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Agricultural Chemical
- Anti-Infective Agents
- Disinfectants
- Fungicide, Bactericide, Wood Preservative
- Human Data
- Insecticide
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Codes
- Known to be a Carcinogen
- Overall Carcinogenic Evaluation: Group 1
- Reportable Quantity (RQ) = 10 lb
- Threshold Planning Quantity (TPQ) = 1000 lb
- TWA (1 ppm); Suspected human carcinogen
- TWA see 1910.1047
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Names and Synonyms
Name of Substance
- Ethylene oxide
MeSH Heading
- Ethylene oxide
Synonyms
- 1,2-Epoxyaethan
- 1,2-Epoxyaethan [German]
- 1,2-Epoxyethane
- Aethylenoxid
- Aethylenoxid [German]
- AI3-26263
- Amprolene
- Anprolene
- Anproline
- Caswell No. 443
- CCRIS 297
- Dihydrooxirene
- Dimethylene oxide
- EC 200-849-9
- EINECS 200-849-9
- ENT-26263
- EPA Pesticide Chemical Code 042301
- Epoxyethane
- Ethene oxide
- Ethyleenoxide
- Ethyleenoxide [Dutch]
- Ethylene (oxyde d')
- Ethylene (oxyde d') [French]
- Ethylene oxide
- Etilene (ossido di)
- Etilene (ossido di) [Italian]
- ETO
- Etylenu tlenek
- Etylenu tlenek [Polish]
- FEMA No. 2433
- HSDB 170
- Merpol
- NCI-C50088
- Oxacyclopropane
- Oxane
- Oxidoethane
- Oxiraan
- Oxiraan [Dutch]
- Oxiran
- Oxirane
- Oxirene, dihydro-
- Oxyfume
- Oxyfume 12
- RCRA waste number U115
- T-Gas
- UN 1040
- UNII-JJH7GNN18P
Systematic Names
- Ethylene oxide
- Oxirane
Superlist Names
- Ethylene oxide
- Ethylene oxide (30% or less), propylene oxide mixture
- Ethylene oxide, or ethlene oxide with nitrogen up to a total pressure of 1Mpa (10 bar) at 50 degrees C
- Ethylene oxide, or ethlene oxide with nitrogen up to a total pressure of 1Mpa (10 bar) at 50 degrees C [UN1040] [Poison gas]
- Oxirane
- RCRA waste no. U115
- UN1040
Registry Numbers
CAS Registry Number
- 75-21-8
FDA UNII
- JJH7GNN18P
Other Registry Numbers
- 142175-32-4
- 184288-32-2
- 19034-08-3
- 37341-05-2
- 436859-78-8
- 99932-75-9
System Generated Number
- 0000075218
Structure Descriptors
InChI
InChI=1S/C2H4O/c1-2-3-1/h1-2H2InChIKey
IAYPIBMASNFSPL-UHFFFAOYSA-NSmiles
C1CO1Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | subcutaneous | 100mg/kg (100mg/kg) | "Beitrage zur Toxikologie des Athylenoxyds und der Glykole, Dissertation," Hofbauer, A., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933. | |
dog | LC50 | inhalation | 960ppm/4H (960ppm) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956. |
dog | LD50 | intravenous | 330mg/kg (330mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Journal of Thoracic and Cardiovascular Surgery. Vol. 61, Pg. 309, 1971. |
guinea pig | LC50 | inhalation | 1500mg/m3/4H (1500mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 67, 1982. | |
guinea pig | LD50 | oral | 270mg/kg (270mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. | |
human | TCLo | inhalation | 12500ppm/10S (12500ppm) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | Journal of Hygiene. Vol. 32, Pg. 409, 1932. |
mouse | LC50 | inhalation | 836ppm/4H (836ppm) | National Technical Information Service. Vol. PB214-270, | |
mouse | LD50 | intraperitoneal | 175mg/kg (175mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(1), Pg. 23, 1983. | |
mouse | LD50 | intravenous | 290mg/kg (290mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 43, Pg. 69, 1978. | |
rabbit | LDLo | intravenous | 175mg/kg (175mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: REGIDITY | Journal of Hygiene. Vol. 32, Pg. 409, 1932. |
rat | LC50 | inhalation | 800ppm/4H (800ppm) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 258, 1969. |
rat | LD50 | oral | 72mg/kg (72mg/kg) | Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 17, 1978. | |
rat | LD50 | subcutaneous | 187mg/kg (187mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(1), Pg. 23, 1983. | |
rat | LDLo | unreported | 200mg/kg (200mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 258, 1969. |
women | TCLo | inhalation | 500ppm/2M (500ppm) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING | Drug Intelligence and Clinical Pharmacy. Vol. 15, Pg. 384, 1981. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -1.12E+02 | deg C | EXP | |
Boiling Point | 10.6 | deg C | EXP | |
log P (octanol-water) | -0.3 | (none) | EXP | |
Water Solubility | 1.00E+06 | mg/L | 25 | EXP |
Vapor Pressure | 1310 | mm Hg | 25 | EXP |
Henry's Law Constant | 1.48E-04 | atm-m3/mole | 25 | EXP |
Atmospheric OH Rate Constant | 7.60E-14 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.