Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: 1,2-Propylene oxide
RN: 75-56-9
UNII: Y4Y7NYD4BK
InChIKey: GOOHAUXETOMSMM-UHFFFAOYSA-N

Molecular Formula

  • C3-H6-O

Molecular Weight

  • 58.0794
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Carcinogens
  • Fungicide, Bactericide, Wood Preservative
  • Human Data
  • Insecticide
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2B
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 100 lb
  • Threshold Planning Quantity (TPQ) = 10000 lb
  • TWA (2 ppm); Sensitizer; Confirmed animal carcinogen with unknown relevance to humans
  • TWA 100 ppm (240 mg/m3)

Names and Synonyms

Name of Substance

  • 1,2-Propylene oxide
  • Propylene oxide

Synonyms

  • 1,2-Epoxypropane
  • 1,2-Propylene oxide
  • 2,3-Epoxypropane
  • 5-17-01-00017 (Beilstein Handbook Reference)
  • AD 6 (suspending agent)
  • AI3-07541
  • BRN 0079763
  • Caswell No. 713A
  • CCRIS 540
  • EC 200-879-2
  • EINECS 200-879-2
  • EPA Pesticide Chemical Code 042501
  • Epoxypropane
  • Ethylene oxide, methyl-
  • HSDB 173
  • Methyl ethylene oxide
  • Methyl oxirane
  • Methyloxacyclopropane
  • Methyloxirane
  • NCI-C50099
  • Oxirane, methyl-
  • Oxyde de propylene
  • Oxyde de propylene [French]
  • Propane, epoxy-
  • Propene oxide
  • Propylene epoxide
  • Propylene oxide
  • Propyleneoxide
  • UNII-Y4Y7NYD4BK

Systematic Names

  • Methyloxirane
  • Oxirane, 2-methyl-
  • Oxirane, methyl-
  • Propane, 1,2-epoxy-
  • Propylene oxide

Superlist Names

  • 1,2-Epoxypropane
  • 1,2-Propylene oxide
  • Epoxypropane
  • Oxirane, methyl-
  • Propylene oxide
  • Propylene oxide [UN1280] [Flammable liquid]
  • UN1280

Registry Numbers

CAS Registry Number

  • 75-56-9

FDA UNII

  • Y4Y7NYD4BK

Other Registry Number

  • 16033-71-9

System Generated Number

  • 0000075569

Structure Descriptors

InChI

1S/C3H6O/c1-3-2-4-3/h3H,2H2,1H3

InChIKey

GOOHAUXETOMSMM-UHFFFAOYSA-N

Smiles

C1[C@@H](O1)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LCLo inhalation 2005ppm/4H (2005ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
guinea pig LCLo inhalation 4000ppm/4H (4000ppm) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS

SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE
AMA Archives of Industrial Health. Vol. 13, Pg. 228, 1956.
guinea pig LD50 oral 660mg/kg (660mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LIVER: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(7), Pg. 76, 1981.
mammal (species unspecified) LD50 oral 440mg/kg (440mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
man TCLo inhalation 1400gm/m3/10M (1400000mg/m3) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: HEADACHE
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 48, 1971.
mouse LC50 inhalation 1740ppm/4H (1740ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
mouse LD50 intraperitoneal 175mg/kg (175mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 103, 1982.
mouse LD50 oral 440mg/kg (440mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 55, 1970.
rabbit LD50 skin 1500uL/kg (1.5mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LC50 inhalation 4000ppm/4H (4000ppm) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
rat LD50 intraperitoneal 150mg/kg (150mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 103, 1982.
rat LD50 oral 380mg/kg (380mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 55, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.12E+02 deg C   EXP
Boiling Point 35 deg C   EXP
log P (octanol-water) 0.03 (none)   EXP
Water Solubility 5.90E+05 mg/L 25 EXP
Vapor Pressure 538 mm Hg 25 EXP
Henry's Law Constant 6.96E-05 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.20E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.