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Substance Name: Fusidate Sodium [USAN]
RN: 751-94-0
UNII: J7P3696BCQ
InChIKey: HJHVQCXHVMGZNC-JCJNLNMISA-M

Note

  • An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

Molecular Formula

  • C31-H48-O6.Na

Molecular Weight

  • 538.6963
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Fusidate Sodium [USAN]

Synonyms

  • CEM-102
  • EINECS 212-030-3
  • Fucidin
  • Fucidina
  • Fucidine
  • Fusidate sodium
  • Fusidic acid, sodium salt
  • Fusidin
  • Fusin
  • Intertulle fucidin
  • Sodium 3alpha,11alpha,16beta-trihydroxy-29-nor-8alpha,9beta,13alpha,14beta-dammara-17(20),24-dien-21-oate 16-acetate
  • Sodium fusidate
  • Sodium fusidin
  • SQ 16360
  • UNII-J7P3696BCQ
  • ZN 6-NA

Systematic Names

  • 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, monosodium salt, (3alpha,4alpha,8alpha,9beta,11alpha,13alpha,14beta,16beta,17Z)-
  • Fusidic acid, sodium salt
  • Sodium fusidate

Registry Numbers

CAS Registry Number

  • 751-94-0

FDA UNII

  • J7P3696BCQ

Other Registry Numbers

  • 1110-01-6
  • 1394-43-0
  • 20291-17-2

Related Registry Number

  • 6990-06-3 (Parent)

System Generated Number

  • 0000751940

Molecular Formulas

Molecular Formula

  • C31-H48-O6.Na

Molecular Formula Fragments

  • C31-H48-O6
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

InChIKey

HJHVQCXHVMGZNC-JCJNLNMISA-M

Smiles

[Na+].C(=O)([O-])C(=C1\[C@@H](OC(=O)C)C[C@@]2([C@@]3(CC[C@H]4[C@@H]([C@@H](CC[C@@]4(C)[C@@H]3[C@H](O)C[C@@H]12)O)C)C)C)\CC\C=C(\C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 170mg/kg (170mg/kg)   Lancet. Vol. 1, Pg. 928, 1962.
mouse LD50 intravenous 205mg/kg (205mg/kg)   Drugs in Japan Vol. 6, Pg. 675, 1982.
mouse LD50 oral 975mg/kg (975mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 1803, 1967.
mouse LD50 subcutaneous 313mg/kg (313mg/kg)   Lancet. Vol. 1, Pg. 928, 1962.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 675, 1982.