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Substance Name: Paromomycin [INN:BAN]
RN: 7542-37-2
UNII: 61JJC8N5ZK
InChIKey: UOZODPSAJZTQNH-LSWIJEOBSA-N

Note

  • An oligosaccharide antibiotic produced by various STREPTOMYCES.

Molecular Formula

  • C23-H45-N5-O14

Molecular Weight

  • 615.6295
 

Classification Codes

  • Amebicides
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Natural Product

Names and Synonyms

Name of Substance

  • Paromomycin
  • Paromomycin [INN:BAN]
  • Paromomycin [INN]

MeSH Heading

  • Paromomycin

Synonyms

  • 4-18-00-07534 (Beilstein Handbook Reference)
  • Aminosidin
  • Aminosidine
  • Aminosidine I
  • Amminosidin
  • Antibiotic 2230D
  • Antibiotic 503-3
  • Antibiotic SF 767B
  • BRN 0072285
  • Crestomycin
  • EINECS 231-423-0
  • Estomycin
  • Gabbromicina
  • Gabbromycin
  • Gabromycin
  • Humycin
  • Hydroxymycin
  • Monomycin A
  • Neomycin E
  • Paromomicina
  • Paromomicina [INN-Spanish]
  • Paromomycin
  • Paromomycin I
  • Paromomycine
  • Paromomycine [INN-French]
  • Paromomycinum
  • Paromomycinum [INN-Latin]
  • Paucimycin
  • Paucimycinum
  • Quintomycin C
  • R 400
  • UNII-61JJC8N5ZK
  • Zygomycin A1

Systematic Names

  • D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-
  • Paromomycin
  • Streptamine, O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxy-

Registry Numbers

CAS Registry Number

  • 7542-37-2

FDA UNII

  • 61JJC8N5ZK

Other Registry Numbers

  • 10010-79-4
  • 11002-84-9
  • 11002-85-0
  • 11021-48-0
  • 11035-13-5
  • 1389-70-4
  • 1390-73-4
  • 1391-98-6
  • 25329-75-3
  • 59-04-1

Related Registry Numbers

  • 1263-89-4 (sulfate)
  • 35665-49-7 (sulfate (2:5))
  • 7205-49-4 (sulfate (1:1))

System Generated Number

  • 0007542372

Structure Descriptors

InChI

1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

InChIKey

UOZODPSAJZTQNH-LSWIJEOBSA-N

Smiles

NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 930mg/kg (930mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 332, 1967.
mouse LD50 intravenous 90mg/kg (90mg/kg)   Presse Medicale. Vol. 70, Pg. 127, 1962.
mouse LD50 oral 2275mg/kg (2275mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 674, 1978.
mouse LD50 subcutaneous 423mg/kg (423mg/kg)   Presse Medicale. Vol. 70, Pg. 127, 1962.
rabbit LD50 intramuscular 1gm/kg (1000mg/kg)   Chemotherapy Vol. 16, Pg. 124, 1968.
rat LD50 intramuscular 1200mg/kg (1200mg/kg) BEHAVIORAL: REGIDITY

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Chemotherapy Vol. 16, Pg. 124, 1968.
rat LD50 intravenous 156mg/kg (156mg/kg)   Presse Medicale. Vol. 70, Pg. 127, 1962.
rat LD50 oral 21620mg/kg (21620mg/kg)   Chemotherapy Vol. 16, Pg. 124, 1968.
rat LD50 oral 21620mg/kg (21620mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Chemotherapy Vol. 16, Pg. 124, 1968.
rat LD50 subcutaneous 1010mg/kg (1010mg/kg)   Antibiotics and Chemotherapy Vol. 12, Pg. 243, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -6.920 (none)   EST
Atmospheric OH Rate Constant 4.23E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.