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Substance Name: Regorafenib [USAN:INN]
RN: 755037-03-7
UNII: 24T2A1DOYB
InChIKey: FNHKPVJBJVTLMP-UHFFFAOYSA-N

Notes

  • Has antineoplastic activity.

    NCI: An orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. (NCI Thesaurus)
  • Has both antiangiogenic and antineoplastic activities.

Molecular Formula

  • C21-H15-Cl-F4-N4-O3

Molecular Weight

  • 482.8195
 

Classification Code

  • Antineoplastic Agents

Names and Synonyms

Name of Substance

  • Regorafenib [USAN:INN]

Synonyms

  • BAY 73-4506
  • BAY73-4506
  • Regorafenib
  • Regorafenibum
  • Stivarga
  • UNII-24T2A1DOYB

Systematic Name

  • 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl}amino)-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

Registry Numbers

CAS Registry Number

  • 755037-03-7

FDA UNII

  • 24T2A1DOYB

System Generated Number

  • 0755037037

Structure Descriptors

InChI

1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

InChIKey

FNHKPVJBJVTLMP-UHFFFAOYSA-N

Smiles

CNC(=O)c1cc(ccn1)Oc2ccc(c(c2)F)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl