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Substance Name: Volasertib [USAN:INN]
RN: 755038-65-4
UNII: 6EM57086EA
InChIKey: SXNJFOWDRLKDSF-STROYTFGSA-N

Note

  • A polo-like kinase inhibitor with broad antitumor activity.

    NCI: A dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Volasertib selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. (NCI Thesaurus)

Molecular Formula

  • C34-H50-N8-O3

Molecular Weight

  • 618.822
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Name of Substance

  • Volasertib [USAN:INN]

Synonyms

  • BI 6727
  • UNII-6EM57086EA
  • Volasertib

Systematic Name

  • Benzamide, N-(trans-4-(4-(cyclopropylmethyl)-1-piperazinyl)cyclohexyl)-4-(((7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl)amino)-3-methoxy-

Registry Numbers

CAS Registry Number

  • 755038-65-4

FDA UNII

  • 6EM57086EA

System Generated Number

  • 0755038654

Structure Descriptors

InChI

1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1

InChIKey

SXNJFOWDRLKDSF-STROYTFGSA-N

Smiles

C(=O)(c1cc(c(cc1)Nc1nc2c(cn1)N(C(=O)[C@H](N2C(C)C)CC)C)OC)N[C@H]1CC[C@@H](CC1)N1CCN(CC1)CC1CC1