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Substance Name: Fomepizole [USAN:INN:BAN]
RN: 7554-65-6
UNII: 83LCM6L2BY
InChIKey: RIKMMFOAQPJVMX-UHFFFAOYSA-N

Note

  • A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.

Molecular Formula

  • C4-H6-N2

Molecular Weight

  • 82.1054
 

Classification Codes

  • Antidote (Alcohol Dehydrogenase Inhibitor)
  • Antidotes
  • Enzyme Inhibitors
  • Protective Agents
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Names and Synonyms

Name of Substance

  • Fomepizole
  • Fomepizole [USAN:INN:BAN]

MeSH Heading

  • Fomepizole

Synonyms

  • 4-Methylpyrazol
  • 4-Methylpyrazole
  • 4-MP
  • 5-23-05-00031 (Beilstein Handbook Reference)
  • Antizol
  • Antizol-vet
  • BRN 0105204
  • EC 231-445-0
  • EINECS 231-445-0
  • Fomepizol
  • Fomepizol [INN-Spanish]
  • Fomepizole
  • Fomepizolum
  • Fomepizolum [INN-Latin]
  • NSC 760365
  • UNII-83LCM6L2BY

Systematic Names

  • 1H-Pyrazole, 4-methyl-
  • 4-Methylpyrazole
  • Pyrazole, 4-methyl-

Registry Numbers

CAS Registry Number

  • 7554-65-6

FDA UNII

  • 83LCM6L2BY

System Generated Number

  • 0007554656

Structure Descriptors

InChI

InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)

InChIKey

RIKMMFOAQPJVMX-UHFFFAOYSA-N

Smiles

Cc1cn[nH]c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 310mg/kg (310mg/kg)   Experientia. Vol. 28, Pg. 1198, 1972.
mouse LD50 oral 640mg/kg (640mg/kg)   Experientia. Vol. 28, Pg. 1198, 1972.
rat LD50 intravenous 310mg/kg (310mg/kg)   Experientia. Vol. 28, Pg. 1198, 1972.
rat LD50 oral 534mg/kg (534mg/kg)   Experientia. Vol. 28, Pg. 1198, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Boiling Point 206 deg C   EXP
log P (octanol-water) 0.610 (none)   EST
Atmospheric OH Rate Constant 9.41E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.