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Substance Name: Dilevalol hydrochloride [USAN:JAN]
RN: 75659-08-4
UNII: O5OBT75D2C
InChIKey: WQVZLXWQESQGIF-WJKBNZMCSA-N

Classification Codes

  • Anti-Adrenergic (beta-Receptor)
  • Antihypertensive
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H24-N2-O3.Cl-H

Molecular Weight

  • 364.871
 
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Names and Synonyms

Name of Substance

  • Dilevalol hydrochloride
  • Dilevalol hydrochloride [USAN:JAN]

Synonyms

  • (-)-5-((1R)-1-Hydroxy-2-(((1R)-1-methyl-3-phenylpropyl)amino)ethyl)salicylamide monohydrochloride
  • (R,R)-5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)salicylamide hydrochloride
  • (R,R)-Dilevalol hydrochloride
  • (R,R)-Labetalol hydrochloride
  • Benzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-, monohydrochloride, (R-(R*,R*))-
  • Dilevalol HCl
  • Dilevalol hydrochloride
  • Sch 19927
  • UNII-O5OBT75D2C

Systematic Name

  • Benzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-, monohydrochloride, (R-(R*,R*))-

Registry Numbers

CAS Registry Number

  • 75659-08-4

FDA UNII

  • O5OBT75D2C

System Generated Number

  • 0075659084

Molecular Formulas

Molecular Formula

  • C19-H24-N2-O3.Cl-H

Molecular Formula Fragments

  • C19-H24-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H/t13-,18+;/m1./s1

InChIKey

WQVZLXWQESQGIF-WJKBNZMCSA-N

Smiles

C([C@H](NC[C@@H](c1cc(c(O)cc1)C(N)=O)O)C)Cc1ccccc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1079mg/kg (1079mg/kg)   Drugs in Japan Vol. -, Pg. 502, 1990.
mouse LD50 intravenous 77200ug/kg (77.2mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1022, 1990.
mouse LD50 oral 1079mg/kg (1079mg/kg)   Drugs in Japan Vol. -, Pg. 502, 1990.
mouse LD50 subcutaneous 1148mg/kg (1148mg/kg)   Drugs in Japan Vol. -, Pg. 502, 1990.
rat LD50 intraperitoneal 123mg/kg (123mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Fundamental and Applied Toxicology. Vol. 18, Pg. 471, 1992.
rat LD50 intravenous 82mg/kg (82mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TREMOR
Fundamental and Applied Toxicology. Vol. 18, Pg. 471, 1992.
rat LD50 oral 1026mg/kg (1026mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Fundamental and Applied Toxicology. Vol. 18, Pg. 471, 1992.
rat LD50 subcutaneous 1727mg/kg (1727mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Fundamental and Applied Toxicology. Vol. 18, Pg. 471, 1992.