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Substance Name: Isradipine [USAN:USP:INN:BAN]
RN: 75695-93-1
UNII: YO1UK1S598
InChIKey: HMJIYCCIJYRONP-UHFFFAOYSA-N

Note

  • A potent antagonist of CALCIUM CHANNELS that is highly selective for vascular smooth muscle. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.

Molecular Formula

  • C19-H21-N3-O5

Molecular Weight

  • 371.3909
 

Classification Codes

  • Antagonist (Calcium Channel)
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Calcium-Regulating Hormones and Agents
  • Cardiovascular Agents
  • Membrane Transport Modulators
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Isradipine
  • Isradipine [USAN:USP:INN:BAN]

MeSH Heading

  • Isradipine

Synonyms

  • (+-)-Isradipine
  • DynaCirc
  • DynaCirc CR
  • Isopropyl methyl (+-)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Isradipin
  • Isradipine
  • Isradipino
  • Isradipino [Spanish]
  • Isradipinum
  • Isradipinum [Latin]
  • Lomir
  • NSC 759892
  • PN 200
  • PN 200-110
  • UNII-YO1UK1S598

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
  • 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
  • 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester, (+-)-

Registry Numbers

CAS Registry Number

  • 75695-93-1

FDA UNII

  • YO1UK1S598

Other Registry Number

  • 88977-22-4

System Generated Number

  • 0075695931

Structure Descriptors

InChI

InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3

InChIKey

HMJIYCCIJYRONP-UHFFFAOYSA-N

Smiles

COC(=O)C1=C(C)NC(=C(C1c2cccc3nonc23)C(=O)OC(C)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1200ug/kg (1.2mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992.
mouse LD50 oral 216mg/kg (216mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992.
rabbit LD50 intravenous 1200ug/kg (1.2mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992.
rabbit LD50 oral 58mg/kg (58mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992.
rat LD50 intravenous 1800ug/kg (1.8mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992.
rat LD50 oral > 3gm/kg (3000mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.28 (none)   EXP
Atmospheric OH Rate Constant 1.36E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.