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Substance Name: Isradipine [USAN:USP:INN:BAN]
RN: 75695-93-1
UNII: YO1UK1S598
InChIKey: HMJIYCCIJYRONP-UHFFFAOYSA-N
Note
- A potent antagonist of CALCIUM CHANNELS that is highly selective for vascular smooth muscle. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
Molecular Formula
- C19-H21-N3-O5
Molecular Weight
- 371.3909
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antagonist (Calcium Channel)
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Isradipine
- Isradipine [USAN:USP:INN:BAN]
MeSH Heading
- Isradipine
Synonyms
- (+-)-Isradipine
- DynaCirc
- DynaCirc CR
- Isopropyl methyl (+-)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
- Isradipin
- Isradipine
- Isradipino
- Isradipino [Spanish]
- Isradipinum
- Isradipinum [Latin]
- Lomir
- NSC 759892
- PN 200
- PN 200-110
- UNII-YO1UK1S598
Systematic Names
- 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
- 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
- 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester, (+-)-
Registry Numbers
CAS Registry Number
- 75695-93-1
FDA UNII
- YO1UK1S598
Other Registry Number
- 88977-22-4
System Generated Number
- 0075695931
Structure Descriptors
InChI
InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3InChIKey
HMJIYCCIJYRONP-UHFFFAOYSA-NSmiles
COC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 1200ug/kg (1.2mg/kg) | Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992. | |
| mouse | LD50 | oral | 216mg/kg (216mg/kg) | Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992. | |
| rabbit | LD50 | intravenous | 1200ug/kg (1.2mg/kg) | Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992. | |
| rabbit | LD50 | oral | 58mg/kg (58mg/kg) | Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992. | |
| rat | LD50 | intravenous | 1800ug/kg (1.8mg/kg) | Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992. | |
| rat | LD50 | oral | > 3gm/kg (3000mg/kg) | Cardiovascular Drug Reviews. Vol. 10, Pg. 3, 1992. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 4.28 | (none) | EXP | |
| Atmospheric OH Rate Constant | 1.36E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.