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Substance Name: Shiga toxin
RN: 75757-64-1

Note

  • A toxin produced by SHIGELLA DYSENTERIAE. It is the prototype of class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA; (RNA, RIBOSOMAL) with PEPTIDE ELONGATION FACTORS.

Molecular Formula

  • Unspecified
 

Classification Code

  • Natural Product
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Links to Resources

Names and Synonyms

Name of Substance

  • Shiga toxin

MeSH Heading

  • Shiga toxin

Synonyms

  • HSDB 8096
  • S. Dysenteriae toxin
  • Shiga toxin
  • Shigatoxin
  • Shigella dysenteriae toxin
  • Shigella dysenteriae type I toxin
  • Shigella toxin (Shigella dysenteriae)
  • Vero cell toxin

Systematic Names

  • Shiga toxin
  • Toxin, shigella dysenteriae

Registry Numbers

CAS Registry Number

  • 75757-64-1

System Generated Number

  • 0075757641

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 250ng/kg (0.00025mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Journal of Immunology. Vol. 130, Pg. 380, 1983.
mouse LD50 intravenous 450ng/kg (0.00045mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Journal of Immunology. Vol. 130, Pg. 380, 1983.
mouse LDLo parenteral 2ug/kg (0.002mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Journal of Neuropathology and Experimental Neurology. Vol. 44, Pg. 496, 1985.
rabbit LD50 intravenous 2200pg/kg (0.0000022mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Journal of Immunology. Vol. 130, Pg. 380, 1983.
rabbit LDLo parenteral 600ng/kg (0.0006mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of Neuropathology and Experimental Neurology. Vol. 44, Pg. 496, 1985.
rat LDLo parenteral 1ug/kg (0.001mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Neuropathology and Experimental Neurology. Vol. 44, Pg. 496, 1985.