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Substance Name: Camphor [USP]
RN: 76-22-2
UNII: 5TJD82A1ET
InChIKey: DSSYKIVIOFKYAU-XCBNKYQSSA-N

Note

  • A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.

Molecular Formula

  • C10-H16-O

Molecular Weight

  • 152.2354
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Antipruritic
  • Drug / Therapeutic Agent
  • Fungicide, Bactericide, Wood Preservative
  • Human Data
  • Mutation Data
  • Natural Product
  • Tumor Data

Superlist Classification Codes

  • TWA (2 ppm); STEL (3 ppm); Not classifiable as a human carcinogen
  • TWA 2 mg/m3

Names and Synonyms

Name of Substance

  • 1,7,7-Trimethylbicyclo(2.2.1)heptan-2-one
  • 2-Bornanone
  • Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
  • Camphor
  • Camphor [USP]
  • Gum camphor
  • Mulberry roots

MeSH Heading

  • Camphor

Synonyms

  • 0-07-00-00135 (Beilstein Handbook Reference)
  • 1,7,7-Trimethylbicyclo(2.2.1)-2-heptanone
  • 1,7,7-Trimethylnorcamphor
  • 2-Bornanone
  • 2-Camphanone
  • 2-Kamfanon
  • 2-Kamfanon [Czech]
  • 2-Keto-1,7,7-trimethylnorcamphane
  • 4-07-00-00213 (Beilstein Handbook Reference)
  • AI3-18783
  • Alphanon
  • Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
  • Bicyclo(2.2.1)heptane-2-one, 1,7,7-trimethyl-
  • Bornane, 2-oxo-
  • BRN 1907611
  • BRN 3196099
  • Camphor
  • Camphor, synthetic
  • Caswell No. 155
  • Cinnamomum camphora
  • DL-Camphor
  • EC 200-945-0
  • EINECS 200-945-0
  • EINECS 244-350-4
  • EPA Pesticide Chemical Code 015602
  • Gum camphor
  • HSDB 37
  • Huile de camphre
  • Huile de camphre [French]
  • Kampfer
  • Kampfer [German]
  • Matricaria camphor
  • Norcamphor, 1,7,7-trimethyl-
  • Root bark oil
  • Spirit of camphor
  • UNII-5TJD82A1ET
  • Zang Qi

Systematic Names

  • (+-)-Camphor
  • Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
  • Bornan-2-one
  • Camphor
  • DL-Bornan-2-one

Superlist Names

  • Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
  • Camphor
  • Camphor, synthetic
  • Camphor, synthetic [UN2717] [Flammable solid]
  • UN2717

Mixture Names

  • Campho-Phenique Cold Sore Gel
  • Campho-Phenique Gel
  • Campho-Phenique Liquid
  • Heet
  • Sarna

Registry Numbers

CAS Registry Number

  • 76-22-2

FDA UNII

  • 5TJD82A1ET

Other Registry Numbers

  • 21368-68-3
  • 48113-22-0
  • 8013-55-6
  • 8022-77-3

System Generated Number

  • 0000076222

Structure Descriptors

InChI

1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3/t7-,10+/m1/s1

InChIKey

DSSYKIVIOFKYAU-XCBNKYQSSA-N

Smiles

CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraperitoneal 400mg/kg (400mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
child LDLo unreported 100mg/kg (100mg/kg)   Yakkyoku. Pharmacy. Vol. 31, Pg. 1499, 1980.
child TDLo oral 51mg/kg (51mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 American Journal of Emergency Medicine. Vol. 7, Pg. 41, 1989.
dog LDLo oral 800mg/kg (800mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog LDLo subcutaneous 240mg/kg (240mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 50, Pg. 199, 1903.
infant LDLo oral 70mg/kg (70mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 American Journal of Pathology. Vol. 30, Pg. 857, 1954.
man LDLo unreported 29mg/kg (29mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LCLo inhalation 400mg/m3/3H (400mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 22(11), Pg. 83, 1957.
mouse LD50 intraperitoneal 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: REGIDITY		 American Journal of Pathology. Vol. 30, Pg. 857, 1954.
mouse LD50 oral 1310mg/kg (1310mg/kg)   Shika Gakuho. Journal of Dentistry. Vol. 75, Pg. 934, 1975.
mouse LDLo subcutaneous 200mg/kg (200mg/kg) BEHAVIORAL: EXCITEMENT "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933.
rabbit LDLo oral 2gm/kg (2000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: REGIDITY		 American Journal of Pathology. Vol. 30, Pg. 857, 1954.
rat LD50 subcutaneous 70mg/kg (70mg/kg)   "Ueber die Pharmakologische Wirkung eines dem Pentamethylentetrazol Vol. -, Pg. -, 1934.
rat LDLo intraperitoneal 900mg/kg (900mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 275, 1939.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 180 deg C   EXP
Boiling Point 204 deg C   EXP
log P (octanol-water) 2.38 (none)   EXP
Water Solubility 1600 mg/L 25 EXP
Vapor Pressure 0.65 mm Hg 25 EXP
Henry's Law Constant 8.10E-05 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.88E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.