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Substance Name: Methoxyflurane [USAN:USP:INN:BAN]
RN: 76-38-0
UNII: 30905R8O7B
InChIKey: RFKMCNOHBTXSMU-UHFFFAOYSA-N

Note

  • An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

Molecular Formula

  • C3-H4-Cl2-F2-O

Molecular Weight

  • 164.9656
 

Classification Codes

  • Anesthetic (Inhalation)
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Inhalation
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Names and Synonyms

Name of Substance

  • Methoxyflurane
  • Methoxyflurane [USAN:USP:INN:BAN]

MeSH Heading

  • Methoxyflurane

Synonyms

  • 2,2-Dichloro-1,1-difluoro-1-methoxyethane
  • 2,2-Dichloro-1,1-difluoroethyl methyl ether
  • 4-02-00-00503 (Beilstein Handbook Reference)
  • Analgizer
  • Anecotan
  • BRN 1737766
  • CCRIS 5840
  • EINECS 200-956-0
  • Ethane, 2,2-dichloro-1,1-difluoro-1-methoxy-
  • HSDB 7201
  • Ingalan
  • Inhalan
  • Methofane
  • Methoflurane
  • Methoxane
  • Methoxifluranum
  • Methoxyfluran
  • Methoxyflurane
  • Methoxyfluranum
  • Methoxyfluranum [INN-Latin]
  • Methyl 1,1-difluoro-2,2-dichloroethyl ether
  • Metofane
  • Metofane (VAN)
  • Metossiflurano
  • Metossiflurano [DCIT]
  • Metoxfluran
  • Metoxifluran
  • Metoxiflurano
  • Metoxiflurano [INN-Spanish]
  • NSC-110432
  • Penthrane
  • Penthrane (VAN)
  • Pentran
  • Pentrane
  • UNII-30905R8O7B

Systematic Names

  • Ethane, 2,2-dichloro-1,1-difluoro-1-methoxy-
  • Ether, 2,2-dichloro-1,1-difluoroethyl methyl
  • Methoxyflurane

Superlist Names

  • Methoxyflurane
  • Methoxyflurane [Anaesthetics, volatile]

Registry Numbers

CAS Registry Number

  • 76-38-0

FDA UNII

  • 30905R8O7B

Other Registry Number

  • 8056-95-9

System Generated Number

  • 0000076380

Structure Descriptors

InChI

1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3

InChIKey

RFKMCNOHBTXSMU-UHFFFAOYSA-N

Smiles

COC(C(Cl)Cl)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TCLo inhalation 3500ppm/1H (3500ppm) KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED Canadian Anaesthetists' Society Journal. Vol. 21, Pg. 294, 1974.
mammal (species unspecified) LC50 inhalation 34gm/m3 (34000mg/m3) BEHAVIORAL: ANTIPSYCHOTIC Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(4), Pg. 55, 1980.
mammal (species unspecified) LD50 oral 3600mg/kg (3600mg/kg) BEHAVIORAL: ANTIPSYCHOTIC Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(4), Pg. 55, 1980.
mouse LC50 inhalation 21500mg/m3 (21500mg/m3) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: EXCITEMENT		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 22(7), Pg. 55, 1978.
mouse LD50 intravenous 150mg/kg (150mg/kg)   United States Patent Document. Vol. #4168308,
rat LC50 inhalation 33500mg/m3/4H (33500mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 53, 1982.
rat LD50 oral 3600mg/kg (3600mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 53, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -3.50E+01 deg C   EXP
Boiling Point 105 deg C   EXP
log P (octanol-water) 2.21 (none)   EXP
Water Solubility 2.83E+04 mg/L 37 EXP
Vapor Pressure 49.1 mm Hg 25 EST
Henry's Law Constant 0.0037 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 3.22E-14 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.