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Substance Name: Heptachlor [BSI:ISO]
RN: 76-44-8
InChIKey: FRCCEHPWNOQAEU-UHFFFAOYSA-N

Note

  • A man-made compound previously used to control termites and other insects. Even though production of heptachlor was phased out of use in the United States during the late 1980's it remains in soil and hazardous waste sites. It is clearly toxic to animals and humans but, the International Agency for Research on Cancer (IARC) has determined that heptachlor is not classifiable as to its carcinogenicity to humans. (From ATSDR Public Heath Statement, April 1989)

Molecular Formula

  • C10-H5-Cl7

Molecular Weight

  • 373.32
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Environmental Pollutants
  • Fungicide, Bactericide, Wood Preservative
  • Insecticide
  • Insecticides
  • Mutation Data
  • Pesticides
  • Reproductive Effect
  • Soil Pollutants
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 34
  • 2011 CERCLA Priority List, Rank: 28
  • Overall Carcinogenic Evaluation: Group 2B
  • Reportable Quantity (RQ) = 1 lb
  • TWA 0.05 mg/m3; skin; Confirmed animal carcinogen with unknown relevance to humans
  • TWA 0.5 mg/m3; skin

Names and Synonyms

Results Name

  • Heptachlor [BSI:ISO]

Name of Substance

  • Heptachlor
  • Heptachlor [BSI:ISO]

MeSH Heading

  • Heptachlor

Synonyms

  • 1(3a),4,5,6,7,8,8-Heptachloro-3a(1),4,7,7a-tetrahydro-4,7-methanoindene
  • 1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-endomethyleneindene
  • 1,4,5,6,7,10,10-Heptachloro-4,7,8,9-tetrahydro-4,7-methyleneindene
  • 1,4,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene
  • 1,4,5,6,7,8,8-Eptacloro-3a,4,7,7a-tetraidro-4,7-endo-metano-indene [Italian]
  • 1,4,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen
  • 1,4,5,6,7,8,8-Heptachloor-3a,4,7,7a-tetrahydro-4,7-endo-methano-indeen [Dutch]
  • 1,4,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden
  • 1,4,5,6,7,8,8-Heptachlor-3a,4,7,7,7a-tetrahydro-4,7-endo-methano-inden [German]
  • 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-endomethanoindene
  • 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene
  • 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanol-1H-indene
  • 1,4,5,6,7,8,8-Heptachlorotetrahydro-4,7-methanoindene
  • 1,4,5,6,7,8,8a-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
  • 3,4,5,6,7,8,8a-Heptachlorodicyclopentadiene
  • 3-Chlorochlordene
  • 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-
  • 4,7-Methanoindene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-
  • Aahepta
  • Agroceres
  • AI3-15152
  • alpha-Dicyclopentadiene, 3,4,5,6,7,8,8A-heptachloro-
  • Arbinex 30TN
  • Basaklor
  • Caswell No. 474
  • CCRIS 324
  • Dicyclopentadiene, 3,4,5,6,7,8,8a-heptachloro-
  • E 3314
  • EINECS 200-962-3
  • ENT 15,152
  • EPA Pesticide Chemical Code 044801
  • Eptacloro
  • Eptacloro [Italian]
  • Gold Crest H-60, Termide
  • GPKh
  • H-34
  • H-60
  • Hepta
  • Heptachloor
  • Heptachloor [Dutch]
  • Heptachlor
  • Heptachlor (technical grade)
  • Heptachlorane
  • Heptachlore
  • Heptachlore [French]
  • Heptachlore [ISO-French]
  • Heptachlorotetrahydro-4,7-methanoindene
  • Heptagran
  • Heptagranox
  • Heptamak
  • Heptamul
  • Heptasol
  • Heptox
  • HSDB 554
  • Latka 104
  • Latka 104 [Czech]
  • NCI-C00180
  • NSC 8930
  • OMS 193
  • RCRA waste number P059
  • Rhodiachlor
  • Soleptax
  • Technical heptachlor
  • Velsicol 104
  • Velsicol heptachlor

Systematic Names

  • 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-
  • 4,7-Methanoindene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-
  • Heptachlor

Superlist Names

  • 1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene
  • 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-
  • Heptachlor
  • Heptachlor and metabolites
  • RCRA waste no. P059

Registry Numbers

CAS Registry Number

  • 76-44-8

Other Registry Numbers

  • 23720-59-4
  • 37229-06-4

System Generated Number

  • 0000076448

Structure Descriptors

InChI

1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H

InChIKey

FRCCEHPWNOQAEU-UHFFFAOYSA-N

Smiles

C1([C@@]2([C@@H]3[C@@H](C=C[C@@H]3Cl)[C@@]1(Cl)C(=C2Cl)Cl)Cl)(Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 150mg/m3/4H (150mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 71, 1982.
cat LDLo oral 50mg/kg (50mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: AGGRESSION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958.
guinea pig LD50 oral 116mg/kg (116mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 576, 1966.
guinea pig LDLo skin 1gm/kg (1000mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: AGGRESSION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958.
hamster LD50 oral 100mg/kg (100mg/kg)   European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974.
mammal (species unspecified) LCLo inhalation 200mg/m3/4H (200mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: AGGRESSION

BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958.
mammal (species unspecified) LD50 unreported 60mg/kg (60mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 59, 1971.
mouse LD50 intracrebral 12mg/kg (12mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toxicology Letters. Vol. 60, Pg. 289, 1992.
mouse LD50 intraperitoneal 130mg/kg (130mg/kg)   Soviet Genetics. English translation of GNKAA5. Vol. 2, Pg. 80, 1966.
mouse LD50 oral 68mg/kg (68mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 12, 1978.
mouse LDLo intravenous 20mg/kg (20mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 107, Pg. 266, 1953.
rabbit LD50 skin 500mg/kg (500mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 2(5), Pg. 15, 1958.
rat LD50 intraperitoneal 27mg/kg (27mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Food and Cosmetics Toxicology. Vol. 11, Pg. 63, 1973.
rat LD50 oral 40mg/kg (40mg/kg)   Pharmaceutical Journal. Vol. 185, Pg. 361, 1960.
rat LD50 skin 119mg/kg (119mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 12, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 95.5 deg C   EXP
Boiling Point 310 deg C   EXP
log P (octanol-water) 6.1 (none)   EXP
Water Solubility 0.18 mg/L 25 EXP
Vapor Pressure 4.00E-04 mm Hg 25 EXP
Henry's Law Constant 2.94E-04 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 6.11E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.