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Substance Name: Rhyncophylline
RN: 76-66-4
UNII: 46BQ79VJ8D
InChIKey: DAXYUDFNWXHGBE-KAXDATADSA-N

Note

  • An oxindole.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C22-H28-N2-O4

Molecular Weight

  • 384.4732
 
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Names and Synonyms

Name of Substance

  • Rhyncophylline

Synonyms

  • Mitrinermin
  • Mitrinermine
  • NSC 21731
  • Rhynchophyllin
  • Rhynchophylline
  • Rhyncophylline
  • Rhynocophylline
  • UNII-46BQ79VJ8D

Systematic Names

  • Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7-beta,16E,20-alpha)-
  • Rhyncophylline (8CI)

Registry Numbers

CAS Registry Number

  • 76-66-4

FDA UNII

  • 46BQ79VJ8D

System Generated Number

  • 0000076664

Structure Descriptors

InChI

1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1

InChIKey

DAXYUDFNWXHGBE-KAXDATADSA-N

Smiles

CC[C@H]1CN2CC[C@@]3([C@@H]2C[C@@H]1\C(=C/OC)\C(=O)OC)C(=O)Nc4ccccc34

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 134mg/kg (134mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 17, 1989.
mouse LD50 intravenous 105mg/kg (105mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 17, 1989.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 216 deg C   EXP
pKa Dissociation Constant 6.4 (none)   EXP
log P (octanol-water) 2.730 (none)   EST
Atmospheric OH Rate Constant 1.47E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.