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Substance Name: Rhyncophylline
RN: 76-66-4
UNII: 46BQ79VJ8D
InChIKey: DAXYUDFNWXHGBE-KAXDATADSA-N
Note
- An oxindole.
Classification Codes
- Drug / Therapeutic Agent
- Natural Product
Molecular Formula
- C22-H28-N2-O4
Molecular Weight
- 384.4732
- All
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
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Names and Synonyms
Name of Substance
- Rhyncophylline
Synonyms
- Mitrinermin
- Mitrinermine
- NSC 21731
- Rhynchophyllin
- Rhynchophylline
- Rhyncophylline
- Rhynocophylline
- UNII-46BQ79VJ8D
Systematic Names
- Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7-beta,16E,20-alpha)-
- Rhyncophylline (8CI)
Registry Numbers
CAS Registry Number
- 76-66-4
FDA UNII
- 46BQ79VJ8D
System Generated Number
- 0000076664
Structure Descriptors
InChI
1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1InChIKey
DAXYUDFNWXHGBE-KAXDATADSA-NSmiles
CC[C@H]1CN2CC[C@@]3([C@@H]2C[C@@H]1\C(=C/OC)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 134mg/kg (134mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 17, 1989. |
| mouse | LD50 | intravenous | 105mg/kg (105mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 17, 1989. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 216 | deg C | EXP | |
| pKa Dissociation Constant | 6.4 | (none) | EXP | |
| log P (octanol-water) | 2.730 | (none) | EST | |
| Atmospheric OH Rate Constant | 1.47E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.