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Substance Name: Thiopental [BAN]
RN: 76-75-5
UNII: JI8Z5M7NA3
InChIKey: IUJDSEJGGMCXSG-UHFFFAOYSA-N
Note
- A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.
Molecular Formula
- C11-H18-N2-O2-S
Molecular Weight
- 242.3412
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anesthetics
- Anesthetics, General
- Anesthetics, Intravenous
- Anticonvulsants
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Modulators
- Hypnotics and Sedatives
- Mutation Data
- Neurotransmitter Agents
- Reproductive Effect
Superlist Classification Code
- DEA Schedule III
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Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Thiopental
- Thiopental [BAN]
MeSH Heading
- Thiopental
Synonyms
- (+-)-Thiopental
- 2-Thio-5-ethyl-5-sec-pentylbarbituric acid
- 5-24-09-00172 (Beilstein Handbook Reference)
- 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid
- BRN 0209361
- EC 200-984-3
- EINECS 200-984-3
- HSDB 7791
- Intraval
- Penthiobarbital
- Pentothiobarbital
- Thiomebumal
- Thionembutal
- Thiopental
- Thiopentobarbital
- Thiopentobarbitone
- Thiopentobarbituric acid
- Thiopentone
- Thiothal
- Tiopentale
- Tiopentale [Italian]
- UNII-JI8Z5M7NA3
Systematic Names
- 4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (9CI)
- 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid
- Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio-
Superlist Names
- DEA No. 2100
- Thiopental
Registry Numbers
CAS Registry Number
- 76-75-5
FDA UNII
- JI8Z5M7NA3
Other Registry Number
- 59709-53-4
System Generated Number
- 0000076755
Structure Descriptors
InChI
1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)InChIKey
IUJDSEJGGMCXSG-UHFFFAOYSA-NSmiles
C1(C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
frog | LD50 | parenteral | 74mg/kg (74mg/kg) | Pharmacology and Toxicology. English translation of FATOAO. Vol. 20, Pg. 569, 1957. | |
mouse | LD50 | intraperitoneal | 110mg/kg (110mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 391, 1960. |
mouse | LD50 | intravenous | 70mg/kg (70mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 441, 1954. | |
mouse | LD50 | oral | 600mg/kg (600mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 215, 1946. | |
mouse | LD50 | parenteral | 90mg/kg (90mg/kg) | Pharmacology and Toxicology. English translation of FATOAO. Vol. 20, Pg. 569, 1957. | |
mouse | LD50 | subcutaneous | 110mg/kg (110mg/kg) | Farmaco. Scienza e Tecnica. Vol. 3, Pg. 269, 1948. | |
rabbit | LDLo | oral | 600mg/kg (600mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 189, 1937. | |
rabbit | LDLo | rectal | 110mg/kg (110mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 189, 1937. | |
rat | LD50 | intraperitoneal | 120mg/kg (120mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 260, 1973. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
pKa Dissociation Constant | 7.55 | (none) | EXP | |
log P (octanol-water) | 2.85 | (none) | EXP | |
Water Solubility | 96 | mg/L | 25 | EST |
Vapor Pressure | 2.15E-10 | mm Hg | 25 | EST |
Henry's Law Constant | 6.35E-09 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.70E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.