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Substance Name: Conopharyngine
RN: 76-98-2
InChIKey: DUFLXLVGASPEMV-KDWZXYONSA-N

Note

  • From Tabernamontana pachysiphon Stapf. var cumminsii (Staph.) H. Huber.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C23-H30-N2-O4

Molecular Weight

  • 398.5
 
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Names and Synonyms

Name of Substance

  • Conopharyngine

Synonyms

  • 18-Carbomethoxy-12,13-dimethoxyibogamine
  • 4-25-00-01286 (Beilstein Handbook Reference)
  • BRN 0060123
  • Conopharyngine (iboga)

Systematic Names

  • Conopharyngine
  • Ibogamine-18-carboxylic acid, 12,13-dimethoxy-, methyl ester (9CI)

Registry Numbers

CAS Registry Number

  • 76-98-2

System Generated Number

  • 0000076982

Structure Descriptors

InChI

1S/C23H30N2O4/c1-5-14-8-13-11-23(22(26)29-4)20-15(6-7-25(12-13)21(14)23)16-9-18(27-2)19(28-3)10-17(16)24-20/h9-10,13-14,21,24H,5-8,11-12H2,1-4H3/t13-,14+,21+,23-/m1/s1

InChIKey

DUFLXLVGASPEMV-KDWZXYONSA-N

Smiles

c1(c(OC)cc2c(c3CC[N@@]4[C@@H]5[C@@](C[C@@H](C[C@@H]5CC)C4)(c3[nH]2)C(=O)OC)c1)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 143mg/kg (143mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 173, 1967.
rat LDLo intraperitoneal 60mg/kg (60mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 173, 1967.