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Substance Name: Metocurine iodide [USAN:USP]
RN: 7601-55-0
UNII: O0U0E87X7F
InChIKey: DIGFQJFCDPKEPF-OIUSMDOTSA-L

Note

  • From Chinese herb Cyclea hainanensis Mrr.

Molecular Formulas

  • C40-H48-I2-N2-O6
  • C40-H48-N2-O6.2I

Molecular Weight

  • 906.627
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Neuromuscular Blocking Agent
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Names and Synonyms

Name of Substance

  • Metocurine iodide [USAN:USP]

Synonyms

  • (+)-O,O'-Dimethylchondrocurarine diiodide
  • 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,18,19,29-tetramethoxy-1,1,14,14-tetramethyl-, diiodide, (13aR-(13aR*,25aS*))-
  • 6,6',7',12'-Tetramethoxy-2,2,2',2'-tetramethyltubocuraranium diiodide
  • Dimethylchondrocurarine iodide
  • Dimethylether of d-tubocurarine iodide
  • EINECS 231-510-3
  • Methyl-curarin
  • Methyl-curarin [German]
  • Metocurine iodide
  • Metubine iodide
  • NSC 36388
  • O,O'-Dimethylchondrocurarine diiodide
  • Tubocurarine, O,O'-dimethyl-, diiodide
  • UNII-O0U0E87X7F

Systematic Names

  • 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,18,19,29-tetramethoxy-1,1,14,14-tetramethyl-, diiodide, (13aR,25aS)-
  • Tubocuraranium, 6,6',7',12'-tetramethoxy-2,2,2',2'-tetramethyl-, diiodide

Registry Numbers

CAS Registry Number

  • 7601-55-0

FDA UNII

  • O0U0E87X7F

Related Registry Number

  • 5152-30-7 (Parent)

System Generated Number

  • 0007601550

Molecular Formulas

Molecular Formulas

  • C40-H48-I2-N2-O6
  • C40-H48-N2-O6.2I

Molecular Formula Fragments

  • C40-H48-N2-O6
  • COMPONENT
  • I

Structure Descriptors

InChI

1S/C40H48N2O6.2HI/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36;;/h9-14,21-24,31-32H,15-20H2,1-8H3;2*1H/q+2;;/p-2/t31-,32+;;/m0../s1

InChIKey

DIGFQJFCDPKEPF-OIUSMDOTSA-L

Smiles

[IH-].[IH-].c12c3c(c(OC)cc2CC[N+]([C@@H]1Cc1cc(Oc2cc4[C@H](Cc5ccc(O3)cc5)[N+](CCc4cc2OC)(C)C)c(OC)cc1)(C)C)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 516, 1949.
man TDLo intravenous 150ug/kg (0.15mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 109, 1948.
mouse LD50 intravenous 230ug/kg (0.23mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 244, Pg. 493, 1963.
rabbit LD50 intravenous 32ug/kg (0.032mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 516, 1949.
rat LD50 intraperitoneal 370ug/kg (0.37mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 109, 1948.
rat LD50 intravenous 35ug/kg (0.035mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Laboratory and Clinical Medicine. Vol. 34, Pg. 516, 1949.